盐酸胍法辛
盐酸胍法辛结构式
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常用名 | 盐酸胍法辛 | 英文名 | guanfacine hydrochloride |
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| CAS号 | 29110-48-3 | 分子量 | 282.554 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C9H10Cl3N3O | 熔点 | 213 °C | |
| MSDS | 中文版 美版 | 闪点 | N/A |
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Functional effects of alcohol withdrawal syndrome on peripheral sympathetic neurotransmission in vas deferens of adult rats.
Life Sci. 108(1) , 34-43, (2014) Alcohol withdrawal syndrome (AWS) is characterized by a set of physiological modifications triggered by abrupt withdrawal and/or decreasing consumption of ethanol (EtOH), which may manifest 16-48 h after ceasing consumption. The relationship between the effec... |
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Researchers seek new ways to counter the harmful toll of stress on the brain.
JAMA 309(4) , 330-2, (2013)
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Cost effectiveness of guanfacine extended-release versus atomoxetine for the treatment of attention-deficit/hyperactivity disorder: application of a matching-adjusted indirect comparison.
Appl. Health Econ. Health Policy 10(6) , 381-95, (2012) About 7% of children and adolescents are diagnosed with attention-deficit/hyperactivity disorder (ADHD) in the US. Patients with ADHD who are intolerant of or do not have an optimal response to stimulants often use non-stimulants as alternative therapies. Gua... |
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Adjuvants to prolong the local anesthetic effects of coated microneedle products
Int. J. Pharm. 439(1-2) , 187-92, (2012) Clonidine prolongs the local residence of lidocaine delivered via sMTS (a coated microneedle system) |
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Unintentional pediatric exposures to central alpha-2 agonists reported to the National Poison Data System.
J. Pediatr. 164(1) , 149-52, (2014) To investigate national trends in unintentional pediatric exposures to 3 common alpha-2 agonists: clonidine, guanfacine, and tizanidine. Secondary objectives were to describe outcomes, symptoms, treatments, and death.Retrospective chart review from the Americ... |
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Metabolic, toxicological, and safety considerations for drugs used to treat ADHD.
Expert Opin. Drug Metab. Toxicol. 8(5) , 543-52, (2012) Pharmacotherapy is frequently used to treat symptoms of attention-deficit/hyperactivity disorder (ADHD), the most common neurobehavioral disorder of childhood. The typically prescribed agents for ADHD have varying durations of effect and degrees of efficacy. ... |
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Dried blood spots as a sampling technique for the quantitative determination of guanfacine in clinical studies.
Bioanalysis 3(22) , 2501-14, (2011) Dried blood spot (DBS) technology was evaluated for the quantitative determination of guanfacine in human blood in clinical studies. A very sensitive DBS assay has been developed using HPLC coupled with an AB Sciex 5500 QTRAP® (Applied Biosystems/MDS Sciex, O... |
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Guanfacine hydrochloride: a centrally acting antihypertensive agent.
Clin. Pharm. 7(3) , 187-97, (1988) The pharmacology, pharmacokinetics, clinical efficacy, adverse effects, and dosage of guanfacine hydrochloride are reviewed. Guanfacine lowers blood pressure by activating CNS alpha adrenoreceptors, which results in sympathetic outflow leading to reduced vasc... |
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Semi-automated direct elution of dried blood spots for the quantitative determination of guanfacine in human blood.
Bioanalysis 4(12) , 1445-56, (2012) Direct analysis of dried blood spot (DBS) samples was investigated using a prototype semi-automated robotic device that allows the direct elution of sample spots from a DBS paper card to an online SPE cartridge. The eluted SPE samples were analyzed with high-... |
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Comparative effectiveness research using matching-adjusted indirect comparison: an application to treatment with guanfacine extended release or atomoxetine in children with attention-deficit/hyperactivity disorder and comorbid oppositional defiant disorder.
Pharmacoepidemiol. Drug Saf. 21 Suppl 2 , 130-7, (2012) The polar flagellar motor of Vibrio alginolyticus rotates using Na(+) influx through the stator, which is composed of 2 subunits, PomA and PomB. About a dozen stators dynamically assemble around the rotor, depending on the Na(+) concentration in the surroundi... |