(D-ARG0,HYP3,D-PHE7,LEU8)-BRADYKININ
(D-ARG0,HYP3,D-PHE7,LEU8)-BRADYKININ结构式
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常用名 | (D-ARG0,HYP3,D-PHE7,LEU8)-BRADYKININ | 英文名 | (D-Arg0,Hyp3,D-Phe7,Leu8)-Bradykinin |
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| CAS号 | 135701-67-6 | 分子量 | 1248.436 | |
| 密度 | 1.5±0.1 g/cm3 | 沸点 | N/A | |
| 分子式 | C57H89N19O13 | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | N/A |
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New highly potent bradykinin B2 receptor antagonists.
Agents Actions 34 , 138-141, (1991) pA2 values of new B2 receptor antagonists ranging from 7.51 to 8.86 were measured on the rabbit jugular vein, while lower values were observed in the other preparations (for instance, the hamster urinary bladder). The most potent antagonists were those contai... |
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Non-selectivity of new bradykinin antagonists for B1 receptors.
Life Sci. 51 , PL 125, (1992) Two new B1 receptor antagonists, [Hyp3,Thi5,DTic7,Oic8]desArg9-BK and DArg[Hyp3,Thi5,DTic7,Oic8]desArg9-BK were tested in vitro on the rabbit jugular vein and the guinea pig ileum (preparations containing B2 receptors) and on the rabbit aorta (preparation con... |
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A new class of bradykinin antagonists: synthesis and in vitro activity of bissuccinimidoalkane peptide dimers.
J. Med. Chem. 35 , 1563, (1992) A systematic study on the dimerization of the bradykinin (BK) antagonist D-Arg0-Arg1-Pro2-Hyp3-Gly4-Phe5-Ser6-D-Phe 7-Leu8-Arg9 has been performed. The first part of this study involved compounds wherein dimerization was carried out by sequentially replacing ... |
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Pharmacological evidence for a single bradykinin B2 receptor in the guinea-pig.
Br. J. Pharmacol. 116(3) , 2106-12, (1995) 1. The present study addresses the possibility of the existence of different kinin B2 receptor subtypes in the guinea-pig by evaluating the affinity of peptide and nonpeptide receptor antagonists. For this purpose, jugular vein rings, ileum segments, lung par... |
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Pharmacological characterization of a new highly potent B2 receptor antagonist (HOE 140: D-Arg-[Hyp3,Thi5,D-Tic7,Qic8]bradykinin).
Eur. J. Pharmacol. 210(2) , 115-20, (1992) HOE 140 (D-Arg-[Hyp3,Thi5,D-Tic7,Oic8]bradykinin), a new B2 antagonist, was compared to R-493 (D-Arg[Hyp3-D-Phe7,Leu8]bradykinin) with respect to inhibition of the responses of seven isolated smooth muscle preparations to bradykinin. R-493 was found to exert:... |