牛磺罗定
牛磺罗定结构式
|
常用名 | 牛磺罗定 | 英文名 | Taurolidine |
|---|---|---|---|---|
| CAS号 | 19388-87-5 | 分子量 | 284.356 | |
| 密度 | 1.5±0.1 g/cm3 | 沸点 | 471.2±55.0 °C at 760 mmHg | |
| 分子式 | C7H16N4O4S2 | 熔点 | 156ºC | |
| MSDS | 美版 | 闪点 | 238.8±31.5 °C |
|
Taurolidine induces epithelial-mesenchymal transition via up-regulation of the transcription factor Snail in human pancreatic cancer cell lines.
Int. J. Colorectal Dis. 29(11) , 1339-48, (2014) The taurine derivative taurolidine (TRD) exerts anti-neoplastic effects in a variety of tumor models. On the other hand, TRD at low doses was shown to reduce cell-cell adhesion, a prerequisite for metastasis. The aim of this study was to elucidate the effects... |
|
|
Central venous catheters and catheter locks in children with cancer: a prospective randomized trial of taurolidine versus heparin.
Pediatr. Blood Cancer 60(8) , 1292-8, (2013) To determine if the catheter lock taurolidine can reduce the number of catheter-related bloodstream infections (CRBSI) in pediatric cancer patients with tunneled central venous catheters (CVC).During a study period of 34 months, 129 newly placed tunneled CVCs... |
|
|
Taurolidine specifically inhibits growth of neuroblastoma cell lines in vitro.
J. Pediatr. Hematol. Oncol. 36(4) , e219-23, (2014) Neuroblastoma is a common pediatric solid tumor with poor outcome for metastatic disease. Thus, novel therapeutic options are of main interest. The anti-neoplastic properties of taurolidine have been demonstrated on a variety of human cancer cells. However, d... |
|
|
Efficacy of taurolidine against periodontopathic species--an in vitro study.
Clin. Oral Investig. 16(3) , 735-44, (2012) The antimicrobial effect of taurolidine was tested against periodontopathic species in comparison to chlorhexidine digluconate in the presence or absence of serum. Minimal inhibitory concentrations (MIC), microbiocidal concentrations (MBC), as well as killing... |
|
|
Randomized controlled trial of taurolidine citrate versus heparin as catheter lock solution in paediatric patients with haematological malignancies.
J. Hosp. Infect. 80(4) , 304-9, (2012) A catheter lock solution containing 1.35% taurolidine and 4% citrate could potentially disrupt bacterial surface adherence and consecutive biofilm production due to the anti-adherence properties of taurolidine and the anticlotting and chelator activities of b... |
|
|
Approaches to prolong the use of uncuffed hemodialysis catheters: results of a randomized trial.
Am. J. Nephrol. 33(3) , 260-8, (2011) Use of uncuffed catheters (UCs) in hemodialysis patients is common practice. An antibiotic lock has been recommended to prevent catheter-related bacteremia (CRB), although insufficient data are available about the appropriate antimicrobial agent and dose with... |
|
|
The effects of taurolidine alone and in combination with doxorubicin or carboplatin in canine osteosarcoma in vitro.
BMC Vet. Res. 9 , 15, (2013) Osteosarcoma (OS) affects over 8000 dogs/year in the United States. The disease usually arises in the appendicular skeleton and metastasizes to the lung. Dogs with localized appendicular disease benefit from limb amputation and chemotherapy but most die withi... |
|
|
Synergistic effects of sonoporation and taurolidin/TRAIL on apoptosis in human fibrosarcoma.
Ultrasound Med. Biol. 36(11) , 1893-906, (2010) Sonodynamic therapy, in combination with ultrasound contrast agents, proved to enhance the uptake of chemotherapeutics in malignant cells. HT1080 fibrosarcoma cells were treated in vitro with a combination of ultrasound SonoVue™-microbubbles and taurolidine (... |
|
|
Observational study of need for thrombolytic therapy and incidence of bacteremia using taurolidine-citrate-heparin, taurolidine-citrate and heparin catheter locks in patients treated with hemodialysis.
Semin. Dial. 25(2) , 233-8, (2012) Catheter-related blood stream infections may be reduced by interdialytic locking with Taurolidine, a nontoxic antimicrobial agent. A formulation of 1.35% Taurolidine in 4% citrate (TC) is associated with a greater need for thrombolysis to maintain catheter pa... |
|
|
Taurolidine lock solution in the secondary prevention of central venous catheter-associated bloodstream infection in home parenteral nutrition patients.
Clin. Nutr. 31(4) , 567-70, (2012) Central venous catheter-associated bloodstream infection (CBSI) is a serious complication in patients on home parenteral nutrition (HPN). The aim was to analyze the impact of taurolidine-citrate lock solution (TLS) on CBSI rate in HPN patients with a high ris... |