奥苯达唑
奥苯达唑结构式
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常用名 | 奥苯达唑 | 英文名 | Oxibendazole |
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| CAS号 | 20559-55-1 | 分子量 | 249.266 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 459ºC | |
| 分子式 | C12H15N3O3 | 熔点 | 230-231°C | |
| MSDS | 中文版 美版 | 闪点 | N/A |
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Developing structure-activity relationships for the prediction of hepatotoxicity.
Chem. Res. Toxicol. 23 , 1215-22, (2010) Drug-induced liver injury is a major issue of concern and has led to the withdrawal of a significant number of marketed drugs. An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification o... |
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A predictive ligand-based Bayesian model for human drug-induced liver injury.
Drug Metab. Dispos. 38 , 2302-8, (2010) Drug-induced liver injury (DILI) is one of the most important reasons for drug development failure at both preapproval and postapproval stages. There has been increased interest in developing predictive in vivo, in vitro, and in silico models to identify comp... |
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Mining biologically-active molecules for inhibitors of fatty acid amide hydrolase (FAAH): Identification of phenmedipham and amperozide as FAAH inhibitors
Bioorg. Med. Chem. Lett. 19 , 6793-6, (2009) The screening of known medicinal agents against new biological targets has been shown to be a valuable approach for revealing new pharmacology of marketed compounds. Recently, carbamate, urea and ketone inhibitors of fatty acid amide hydrolase (FAAH) have bee... |
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Comparison of daily and monthly pyrantel treatment in yearling thoroughbreds and the protective effect of strategic medication of mares on their foals.
Vet. Parasitol. 55(1-2) , 93-104, (1994) Studies on a Thoroughbred breeding farm in Ohio were done to: (1) compare the effects of daily administration of pyrantel tartrate feed pellets with monthly administration of a pyrantel pamoate paste to yearling horses (21 January-3 September); (2) assess the... |
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Depletion and bioavailability of 14C-oxibendazole residues in swine tissues.
Vet. Parasitol. 64(1-2) , 83-93, (1996) Groups of male swine were administered a single oral dose of 14C-oxibendazole in a gelatin capsule at a level of 15 mg kg-1 bodyweight and killed after 10 h, 24 h, and 7 days withdrawal. Combustion analysis indicated that liver was the only tissue which conta... |
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A field evaluation of three methods of administration of anthelminthics to horses.
Equine Vet. J. 24(6) , 487-8, (1992)
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Plasma disposition, faecal excretion and in vitro metabolism of oxibendazole following oral administration in horses.
Res. Vet. Sci. 72(1) , 11-5, (2002) Oxibendazole (OBZ) was administered to eight horses at an oral dose of 10 mg kg(-1) bodyweight each. Parent OBZ could only be detected in plasma at the 0.5 and 1.0 hours post administration sampling times and the mean maximum plasma concentration was 0.008 mi... |
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Ivermectin treatment of horses: effect on the distribution of lawns and roughs in horse pastures.
Vet. Parasitol. 48(1-4) , 241-6, (1993) A study was carried out to assess the feasibility of determining the grazing patterns of horses bimonthly via aerial survey and standard cartographic techniques. The grazing patterns in pastures with equivalent stocking rates of horses treated bimonthly with ... |
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Controlled tests of activity of several antiparasitic compounds against natural infections of Haemonchus contortus and other helminths in lambs from a flock established in 1962.
Am. J. Vet. Res. 54(3) , 406-10, (1993) Antiparasitic activity of several compounds was evaluated over a long period (about 25 years) in the same flock of sheep. Haemonchus contortus was of special interest, including its relation to drug resistance, especially to thiabendazole and other benzimidaz... |
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Efficacy of moxidectin and other anthelmintics against small strongyles in horses.
Aust. Vet. J. 76(5) , 332-4, (1998) To compare the efficacy of moxidectin to ivermectin, oxibendazole and morantel against some gastrointestinal nematodes in horses.Faecal egg count reduction after treatment.A farm was selected where the population of small strongyles in horses was known to be ... |