雷复尼特
雷复尼特结构式
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常用名 | 雷复尼特 | 英文名 | Rafoxanide |
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| CAS号 | 22662-39-1 | 分子量 | 626.010 | |
| 密度 | 2.0±0.1 g/cm3 | 沸点 | 526.6±50.0 °C at 760 mmHg | |
| 分子式 | C19H11Cl2I2NO3 | 熔点 | 169ºC | |
| MSDS | 中文版 美版 | 闪点 | 272.3±30.1 °C |
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The Hymenolepis diminuta-golden hamster (Mesocricetus auratus) model for the evaluation of gastrointestinal anticestode activity.
J. Parasitol. 90(4) , 898-9, (2004) A novel laboratory anticestode assay was developed using Hymenolepis diminuta in the hamster. The commercial anticestode compounds, praziquantel, bunamidine, and niclosamide were active against patent infections of Hymenolepis diminuta in golden hamsters (Mes... |
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An improved thyroid hormone reporter assay to determine the thyroid hormone-like activity of amiodarone, bithionol, closantel and rafoxanide.
Toxicol. Lett. 208(1) , 30-5, (2012) A number of environmental chemicals have been reported to exhibit thyroid hormone-like activity. Since thyroid hormones play a crucial role in development, it is important to identify chemicals in the environment that are capable of endocrine disruption of th... |
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Screening of closantel and rafoxanide in animal muscles by HPLC with fluorescence detection and confirmation using MS.
J. Sep. Sci. 33(2) , 206-11, (2010) A sensitive and selective LC-FLD method was described for determination of closantel and rafoxanide in bovine and ovine muscles. Bovine and ovine muscles were extracted with ACN and acetone mixture (80:20, v/v). After cleanup with Oasis MAX SPE cartridges, th... |
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Determination of closantel and rafoxanide in animal tissues by online anionic mixed-mode solid-phase extraction followed by isotope dilution liquid chromatography tandem mass spectrometry.
J. Sep. Sci. 34(12) , 1366-74, (2011) A rapid and high-throughput isotope dilution LC-MS/MS method with online sample pre-concentration and clean-up using anionic mixed-mode SPE was described for the determination of closantel and rafoxanide in edible bovine and ovine tissues. Tissue samples were... |
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Quantitative analysis of closantel and rafoxanide in bovine and ovine muscles by high-performance liquid chromatography with fluorescence detection.
J. AOAC Int. 93(5) , 1672-7, (2010) An HPLC method with a fluorescence detector (HPLC-FLD) was described for the quantitative determination of closantel and rafoxanide in bovine and ovine muscles. A structural analog closely related to rafoxanide, viz., N-[4-(4-chlorophenoxy)phenyl]-2-hydroxy-3... |
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The efficacy of closantel and rafoxanide against fenbendazole- and levamisole-resistant Haemonchus contortus in small ruminants.
Vet. Res. Commun. 21(7) , 493-7, (1997)
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Effects of the anthelmintics clorsulon, rafoxanide, mebendazole and arprinocid on Echinostoma caproni in ICR mice [corrected and reapublished in J Helminthol 1996 Mar;70(1):95-6].
J. Helminthol. 69(4) , 373-4, (1995) Female ICR mice, 5 to 6 weeks old, were exposed by stomach tube to 25 metacercarial cysts of Echinostoma caproni per mouse. At 14 days post-exposure, mice were fed by stomach tube clorsulon (1000 mg/kg, 500 mg/kg and 100 mg/kg) or rafoxanide (50 mg/kg, 25 mg/... |
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Differences in the oral bioavailability of three rafoxanide formulations in sheep.
J. S. Afr. Vet. Assoc. 66(4) , 197-201, (1995) The bioavailability of a modified rafoxanide oral suspension was compared to the original innovator product and a generic formulation in a single dose, randomised, parallel design study in sheep (n = 30). The area under the rafoxanide plasma concentration ver... |
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Anthelmintic resistance of nematodes in communally grazed goats in a semi-arid area of South Africa.
J. S. Afr. Vet. Assoc. 74(3) , 82-3, (2003) A survey was conducted on the occurrence of anthelmintic resistance of nematodes in communally grazed goats in a semi-arid area in South Africa. In herds belonging to 10 small-holder goat farmers, the efficacies of fenbendazole, levamisole and rafoxanide were... |
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Stability and partitioning of closantel and rafoxanide in ruminal fluid of sheep.
Onderstepoort J. Vet. Res. 67(2) , 97-103, (2000) The stability and the partitioning of closantel and rafoxanide in ruminal fluid (RF) was examined in vitro. Stability was evaluated in two studies in a ruminal fluid-artificial saliva (RF-AS) mixture containing either drug. Drug concentrations were measured i... |