醋酸去氧皮质酮
醋酸去氧皮质酮结构式
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常用名 | 醋酸去氧皮质酮 | 英文名 | Deoxycorticosterone acetate |
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| CAS号 | 56-47-3 | 分子量 | 372.498 | |
| 密度 | 1.1±0.1 g/cm3 | 沸点 | 504.1±50.0 °C at 760 mmHg | |
| 分子式 | C23H32O4 | 熔点 | 157°C | |
| MSDS | 中文版 美版 | 闪点 | 218.0±30.2 °C |
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Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Toxicol. Mech. Methods 18 , 217-27, (2008) ABSTRACT Drug-induced phospholipidosis (PL) is a condition characterized by the accumulation of phospholipids and drug in lysosomes, and is found in a variety of tissue types. PL is frequently manifested in preclinical studies and may delay or prevent the dev... |
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Antibacterial activity of enrofloxacin and ciprofloxacin derivatives of β-octaarginine.
Chem. Biodivers. 12(2) , 179-93, (2015) β(3) -Octaarginine chains were attached to the functional groups NH and CO2 H of the antibacterial fluoroquinolones ciprofloxacin (→1) and enrofloxacin (→2), respectively, in order to find out whether the activity increases by attachment of the polycationic, ... |
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Defensive effect of natrium diethyldithiocarbamate trihydrate (NDDCT) and lisinopril in DOCA-salt hypertension-induced vascular dementia in rats.
Psychopharmacology 223(3) , 307-17, (2012) Vascular dementia and hypertension are increasing day by day, with a high degree of co-occurrence. Tremendous amount of research work is required so that new pharmacological agents may be identified for their appropriate therapeutic utility to combat differen... |
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Comparison of the electrical properties of arterial smooth muscle in normotensive rats and rats with deoxycorticosterone acetate-salt-induced hypertension: possible involvement of (Na(+)-K(+)-Cl-) co-transport.
Clin. Sci. 81(1) , 73-8, (1991) 1. Hypertension was induced in male Sprague-Dawley rats by left unilateral nephrectomy and deoxycorticosterone acetate--salt administration. After 5 weeks, arterial systolic blood pressure was significantly elevated in these animals (191.5 +/- 6.0 mmHg, mean ... |
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Heme arginate suppresses cardiac lesions and hypertrophy in deoxycorticosterone acetate-salt hypertension.
Exp. Biol. Med. (Maywood.) 234(7) , 764-78, (2009) In hypertension, elevated levels of oxidative/inflammatory mediators including nuclear factor kappaB (NF-kappaB), activating protein (AP-1), c-Jun-NH2-terminal kinase (JNK), and cell-regulatory proteins such as transforming growth factor beta (TGF-beta), trig... |
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Ventricular function and natriuretic peptides in sequentially combined models of hypertension.
Am. J. Physiol. Heart Circ. Physiol. 298(4) , H1290-9, (2010) Hemodynamic parameters and natriuretic peptide levels were evaluated in cardiac hypertrophy produced by sequentially applied renovascular (RV) and deoxycorticosterone acetate-salt (DS) models of hypertension. We studied hypertensive rats by RV or DS treatment... |
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DOCA and TGF-beta induce early growth response gene-1 (Egr-1) expression.
Cell Physiol. Biochem. 22(5-6) , 465-74, (2008) Renal fibrosis is characterized by excessive accumulation of extracellular matrix proteins. Recent findings show that transforming growth factor-beta (TGF-beta) induces a rapid but transient expression of early growth response gene-1 (Egr-1) by skin fibroblas... |
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Distal tubule bicarbonate reabsorption during rebound metabolic alkalosis.
Can. J. Physiol. Pharmacol. 69(11) , 1784-8, (1991) Rebound metabolic alkalosis is a transient alkalemia that is seen during recovery from NH4Cl-induced metabolic acidosis. The persistent elevation of plasma bicarbonate concentration is the result of continuing excretion of net acid by the kidney. Bicarbonate ... |
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Mineralocorticoid receptor antagonism prevents hedonic deficits induced by a chronic sodium appetite.
Behav. Neurosci. 124(2) , 211-24, (2010) Our laboratory has reported that manipulations that provoke a robust sodium appetite (e.g., sodium depletion, deoxycorticosterone acetate) decrease lateral hypothalamic self-stimulation (LHSS) reward if rats are denied access to hypertonic saline solutions. T... |
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Tension cost correlates with mechanical and biochemical parameters in different myocardial contractility conditions.
Clinics (Sao. Paulo.) 67(5) , 489-96, (2012) Tension cost, the ratio of myosin ATPase activity to tension, reflects the economy of tension development in the myocardium. To evaluate the mechanical advantage represented by the tension cost, we studied papillary muscle contractility and the activity of my... |