分枝菌酸(牛株)
分枝菌酸(牛株)结构式
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常用名 | 分枝菌酸(牛株) | 英文名 | MYCOLIC ACID |
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| CAS号 | 37281-34-8 | 分子量 | N/A | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | RCH(OH)CHR'COH{混合物} | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | N/A |
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In vitro effect of ursolic acid on the inhibition of Mycobacterium tuberculosis and its cell wall mycolic acid.
Pulm. Pharmacol. Ther. 33 , 17-24, (2015) Mycobacterium tuberculosis is a dangerous intracellular pathogen. In order to protect against mycobacterium infection, novel agents with anti-mycobacterial activity should be given emergency priority for evaluation. Ursolic acid (UA), a plant triterpenoid, sh... |
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Structure of a classical MHC class I molecule that binds "non-classical" ligands.
PLoS Biol. 8 , e1000557, (2010) Chicken YF1 genes share a close sequence relationship with classical MHC class I loci but map outside of the core MHC region. To obtain insights into their function, we determined the structure of the YF1*7.1/β(2)-microgloblin complex by X-ray crystallography... |
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Mycolic acids as diagnostic markers for tuberculosis case detection in humans and drug efficacy in mice.
EMBO Mol. Med. 4 , 27-37, (2012) Mycolic acids are attractive diagnostic markers for tuberculosis (TB) infection because they are bacteria-derived, contain information about bacterial species, modulate host-pathogen interactions and are chemically inert. Here, we present a novel approach bas... |
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Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane.
Nat. Chem. Biol. 8 , 334-341, (2012) New chemotherapeutics active against multidrug-resistant Mycobacterium tuberculosis are urgently needed. We report on the identification of an adamantyl urea compound that shows potent bactericidal activity against M. tuberculosis and a unique mode of action,... |
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SQ109 targets MmpL3, a membrane transporter of trehalose monomycolate involved in mycolic acid donation to the cell wall core of Mycobacterium tuberculosis.
Antimicrob. Agents Chemother. 56 , 1797-1809, (2012) SQ109, a 1,2-diamine related to ethambutol, is currently in clinical trials for the treatment of tuberculosis, but its mode of action remains unclear. Here, we demonstrate that SQ109 disrupts cell wall assembly, as evidenced by macromolecular incorporation as... |
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A mycolic acid-specific CD1-restricted T cell population contributes to acute and memory immune responses in human tuberculosis infection.
J. Clin. Invest. 121 , 2493-2503, (2011) Current tuberculosis (TB) vaccine strategies are largely aimed at activating conventional T cell responses to mycobacterial protein antigens. However, the lipid-rich cell wall of Mycobacterium tuberculosis (M. tuberculosis) is essential for pathogenicity and ... |
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Asselineau, J.
The Bacterial Lipids Paris, New York , (1962), 82
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