Big endothelin-1 (rat 1-39)
Big endothelin-1 (rat 1-39)结构式
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常用名 | Big endothelin-1 (rat 1-39) | 英文名 | Big endothelin-1 (rat 1-39) |
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| CAS号 | 135842-15-8 | 分子量 | 4389 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C192H292N50O58S5 | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | N/A |
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Chronic endothelin receptor blockade attenuates progressive ventricular dilation and improves cardiac function in rats with myocardial infarction: possible involvement of myocardial endothelin system in ventricular remodeling.
Circulation 96(11) , 3963-73, (1997) Left ventricular dilatation after myocardial infarction is associated with impaired ventricular function and heart failure and has important implications for survival. The purpose of this study was to investigate the role of endothelin-1 (ET-1) in ventricular... |
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Phosphoramidon blocks the pressor activity of porcine big endothelin-1-(1-39) in vivo and conversion of big endothelin-1-(1-39) to endothelin-1-(1-21) in vitro.
Proc. Natl. Acad. Sci. U. S. A. 88(3) , 703-7, (1991) In porcine aortic endothelial cells, the 21-amino acid peptide endothelin-1 (ET-1) is formed from a 39-amino acid intermediate called "big endothelin-1" (big ET-1) by a putative ET-converting enzyme (ECE) that cleaves the 39-mer at the bond between Trp-21 and... |
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Phosphoramidon blocks big-endothelin-1 but not endothelin-1 enhancement of vascular permeability in the rat.
Br. J. Pharmacol. 107(4) , 996-1000, (1992) 1. Changes in vascular permeability following intravenous injections of human big-endothelin-1 (big-ET-1) and endothelin-1 (ET-1) were measured by extravasation of Evans blue dye (EB, 20 mg kg-1) in selected tissues. 2. A low dose of big-ET-1 (40 pmol kg-1) f... |
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Vascular matrix metalloproteinase-2 cleaves big endothelin-1 yielding a novel vasoconstrictor.
Circ. Res. 85(10) , 906-11, (1999) Matrix metalloproteinase-2 (MMP-2, gelatinase A) and its tissue inhibitor (TIMP-2) are mainly known for their roles in the (patho)physiological remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaqu... |
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Contraction to big endothelin-1, big endothelin-2 and big endothelin-3, and endothelin-converting enzyme inhibition in human isolated bronchi.
Br. J. Pharmacol. 129 , 170-176, (2000) All three endothelin precursor peptides, i.e. big endothelin-1 (big ET-1), big endothelin-2 (big ET-2) and big endothelin-3 (big ET-3), produced contractile responses in human isolated bronchi, demonstrating the presence of functional endothelin-converting en... |
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cDNA cloning, sequence analysis and tissue distribution of rat preproendothelin-1 mRNA.
Biochem. Biophys. Res. Commun. 175 , 44, (1991) We report the cloning of a full-length cDNA encoding rat preproendothelin-1 (preproET-1). The predicted rat preproET-1 consists of 202 amino acid residues and highly similar to human, porcine and bovine preproET-1, respectively. The deduced 21-residue sequenc... |
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Synthesis and receptor sites of endothelin-1 in the rat liver vasculature.
Anat. Rec. 259 , 437-445, (2000) Immunocytochemical localization of big endothelin-1 (big ET-1), ET-1, and ET receptor A and B (ET(A) and ET(B)), and gene expression of prepro ET-1 mRNA were examined on the rat liver vasculature. Immunoreactivities for big ET-1 and ET-1 were preferentially s... |
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Characterization of the contractile and relaxant action of the endothelin-1 precursor, big endothelin-1, in the isolated rat basilar artery.
Peptides 21 , 91-99, (2000) The presence of functional endothelin converting enzyme (ECE) activity in basilar artery ring segments was investigated by measuring the contractile and relaxant effects of big endothelin (ET)-1. Under resting tension conditions cumulative application of big ... |