肉桂霉素
肉桂霉素结构式
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常用名 | 肉桂霉素 | 英文名 | Cinnamycin |
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| CAS号 | 110655-58-8 | 分子量 | 2041.29 | |
| 密度 | 1.6±0.1 g/cm3 | 沸点 | N/A | |
| 分子式 | C89H125N25O25S3 | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | N/A |
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Effects of docosahexaenoic and arachidonic acids on the synthesis and distribution of aminophospholipids during neuronal differentiation of PC12 cells.
Arch. Biochem. Biophys. 364(1) , 67-74, (1999) We have shown previously that docosahexaenoic acid (DHA) promotes and arachidonic acid (AA) suppresses neurite outgrowth of PC12 cells induced by nerve growth factor (NGF) and that incorporation of [3H]ethanolamine into phosphatidylethanolamine (PE) is suppre... |
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Manipulation of the phosphatidylethanolamine pool in the human red cell membrane affects its Mg2+-ATPase activity.
Mol. Membr. Biol. 13(2) , 95-102, (1996) Decreasing the size of the outer leaflet pool of phosphatidylethanolamine (PE) in the erythrocyte membrane by treatment of intact cells with either phospholipase A2, or trinitrobenzenesulphonic acid (TNBS), causes a corresponding decrease in Mg(2+)-ATPase act... |
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The structure of Ro 09-0198 in different environments.
Biopolymers 32(4) , 427-33, (1992) The constitution and configuration of Ro 09-0198 (cinnamycin) have been determined in DMSO. Further investigations in aqueous solution, in SDS micelles and in a lipid bilayer have been done to study the influence of different environments on the conformation ... |
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Stimulation of sodium transport by duramycin in cultured human colonic epithelia.
J. Pharmacol. Exp. Ther. 259 , 1050, (1991) Effects of two peptide antibiotics, duramycin and Ro 09-0198, on ion transport in cultured human colonic epithelia were investigated. Both peptides acted on the apical face of epithelial monolayers, causing an increase in ion transport measured as short circu... |
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Upregulated function of mitochondria-associated ER membranes in Alzheimer disease.
EMBO J. 31 , 4106-23, (2012) Alzheimer disease (AD) is associated with aberrant processing of the amyloid precursor protein (APP) by γ-secretase, via an unknown mechanism. We recently showed that presenilin-1 and -2, the catalytic components of γ-secretase, and γ-secretase activity itsel... |
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Redistribution of phosphatidylethanolamine at the cleavage furrow of dividing cells during cytokinesis.
Proc. Natl. Acad. Sci. U. S. A. 93(23) , 12867-72, (1996) Ro09-0198 is a tetracyclic polypeptide of 19 amino acids that recognizes strictly the structure of phosphatidylethanolamine (PE) and forms a tight equimolar complex with PE on biological membranes. Using the cyclic peptide coupled with fluorescence-labeled st... |
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Hemolytic activity of a cyclic peptide Ro09-0198 isolated from Streptoverticillium.
Biochim. Biophys. Acta 940(2) , 171-9, (1988) Ro09-0198, a cyclic peptide isolated from culture filtrates of Streptoverticillium griseoverticillatum, induced lysis of erythrocytes. Preincubation of the peptide with phosphatidylethanolamine reduced the hemolytic activity, whereas other phospholipids prese... |
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Interaction of a cyclic peptide, Ro09-0198, with phosphatidylethanolamine in liposomal membranes.
Biochim. Biophys. Acta 940(2) , 180-7, (1988) Ro09-0198 is a cyclic peptide isolated from Streptoverticillium griseoverticillatum. This peptide caused permeability increase and aggregation of liposomes containing phosphatidylethanolamine. Liposomes containing phosphatidylserine, phosphatidylinositol or c... |
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Capacitation induces cyclic adenosine 3',5'-monophosphate-dependent, but apoptosis-unrelated, exposure of aminophospholipids at the apical head plasma membrane of boar sperm cells.
Biol. Reprod. 67(1) , 340-50, (2002) The capacitating agent bicarbonate/CO(2) has been shown to induce profound changes in the architecture and dynamics within the sperm's plasma membrane lipid bilayer via a cAMP-dependent protein phosphorylation signaling pathway. Here we have investigated the ... |
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A novel membrane protein, Ros3p, is required for phospholipid translocation across the plasma membrane in Saccharomyces cerevisiae.
J. Biol. Chem. 277(40) , 37855-62, (2002) Ro09-0198 (Ro) is a tetracyclic peptide antibiotic that binds specifically to phosphatidylethanolamine (PE) and causes cytolysis. To investigate the molecular basis of transbilayer movement of PE in biological membranes, we have isolated a series of budding y... |