组织蛋白酶G 来源于人唾液
组织蛋白酶G 来源于人唾液结构式
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常用名 | 组织蛋白酶G 来源于人唾液 | 英文名 | Cathepsin G from human sputum |
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| CAS号 | 107200-92-0 | 分子量 | N/A | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | N/A | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | N/A |
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Prolonged exposure to neutrophil extracellular traps can induce mitochondrial damage in macrophages and dendritic cells.
Springerplus 4 , 161, (2015) Neutrophils are one the earliest, crucial innate defenses against innumerable pathogens. Their main microbicidal activities include phagocytosis and degranulation, with many pharmacologically active molecules contributing to inflammation. Recently, a novel an... |
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Role of renin-angiotensin system in activation of macrophages by modified lipoproteins.
Am. J. Physiol. Heart Circ. Physiol. 305(9) , H1309-20, (2013) Angiotensin II favors the development of atherosclerosis. Our goal was to determine if foam cell formation increases angiotensin II generation by the endogenous renin-angiotensin system (RAS) and if endogenously produced angiotensin II promotes lipid accumula... |
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Effects of milk casein derived tripeptides on endothelial enzymes in vitro; a study with synthetic tripeptides.
Arzneimittelforschung 62(10) , 477-81, (2012) In the fermentation of milk by certain lactic acid bacteria, casein is degraded into bioactive tripeptides shown to lower blood pressure in experimental animal models and in mildly hypertensive humans. This effect is suggested to result mainly in inhibition o... |
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Cathepsin G induces cell aggregation of human breast cancer MCF-7 cells via a 2-step mechanism: catalytic site-independent binding to the cell surface and enzymatic activity-dependent induction of the cell aggregation.
Mediators Inflamm. 2012 , 456462, (2012) Neutrophils often invade various tumor tissues and affect tumor progression and metastasis. Cathepsin G (CG) is a serine protease secreted from activated neutrophils. Previously, we have shown that CG induces the formation of E-cadherin-mediated multicellular... |
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Simukunin from the salivary glands of the black fly Simulium vittatum inhibits enzymes that regulate clotting and inflammatory responses.
PLoS ONE 7(2) , e29964, (2012) Black flies (Diptera: Simuliidae) feed on blood, and are important vectors of Onchocerca volvulus, the etiolytic agent of River Blindness. Blood feeding depends on pharmacological properties of saliva, including anticoagulation, but the molecules responsible ... |
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Increased surfactant protein D fails to improve bacterial clearance and inflammation in serpinB1-/- mice.
Am. J. Respir. Cell. Mol. Biol. 47(6) , 792-9, (2012) Previously, we described the protective role of the neutrophil serine protease inhibitor serpinB1 in preventing early mortality of Pseudomonas aeruginosa lung infection by fostering bacterial clearance and limiting inflammatory cytokines and proteolytic damag... |
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Global substrate profiling of proteases in human neutrophil extracellular traps reveals consensus motif predominantly contributed by elastase.
PLoS ONE 8(9) , e75141, (2013) Neutrophil extracellular traps (NETs) consist of antimicrobial molecules embedded in a web of extracellular DNA. Formation of NETs is considered to be a defense mechanism utilized by neutrophils to ensnare and kill invading pathogens, and has been recently te... |
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Nonencapsulated Streptococcus pneumoniae resists extracellular human neutrophil elastase- and cathepsin G-mediated killing.
FEMS Immunol. Med. Microbiol. 66(3) , 445-8, (2012) Although the Streptococcus pneumoniae polysaccharide capsule is an important virulence factor, ~ 15% of carriage isolates are nonencapsulated. Nonencapsulated S. pneumoniae are a cause of mucosal infections. Recent studies have shown that neutrophils kill S. ... |
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Poly-L-Lysine compacts DNA, kills bacteria, and improves protease inhibition in cystic fibrosis sputum.
Am. J. Respir. Crit. Care Med. 188(6) , 703-9, (2013) Neutrophil serine proteases in cystic fibrosis (CF) lung secretions partially resist inhibition by natural and exogenous inhibitors, mostly because DNA impairs their control. Cationic polypeptides display the property of condensing DNA and retain antimicrobia... |
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Human leukocyte cathepsin G. Subsite mapping with 4-nitroanilides, chemical modification, and effect of possible cofactors.
Biochemistry 24(8) , 2040-7, (1985) The extended substrate binding site of cathepsin G from human leukocytes has been mapped by using a series of peptide 4-nitroanilide substrates. The enzyme has a significant preference for substrates with a P1 Phe over those with the other aromatic amino acid... |