多聚谷氨酸酪氨酸钠盐
多聚谷氨酸酪氨酸钠盐结构式
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常用名 | 多聚谷氨酸酪氨酸钠盐 | 英文名 | poly(glu, tyr) sodium salt |
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| CAS号 | 97105-00-5 | 分子量 | 954.073 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 951.6±75.0 °C at 760 mmHg | |
| 分子式 | C44H81N3O15P2 | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | 529.3±37.1 °C |
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Decreased insulin receptor tyrosine kinase activity and plasma cell membrane glycoprotein-1 overexpression in skeletal muscle from obese women with gestational diabetes mellitus (GDM): evidence for increased serine/threonine phosphorylation in pregnancy and GDM.
Diabetes 49 , 603-610, (2000) The cellular mechanisms for the insulin resistance of pregnancy and gestational diabetes mellitus (GDM) are unknown. The membrane protein plasma cell membrane glycoprotein-1 (PC-1) has been identified as an inhibitor of insulin receptor tyrosine kinase (IRTK)... |
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Electrochemical detection of tyrosine derivatives and protein tyrosine kinase activity using boron-doped diamond electrodes.
Biosens. Bioelectron. 26 , 235-240, (2010) In this report, we determined protein tyrosine kinase (PTKs) activity in human epidermoid carcinoma cells (A431) by employing a novel electrochemical method using boron-doped diamond (BDD) electrodes that enables the electrochemical oxidation of tyrosine (Tyr... |
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An electrochemical biosensor for the detection of tyrosine oxidation induced by Fenton reaction.
Biosens. Bioelectron. 26 , 2292-2296, (2011) A simple and sensitive electrochemical biosensor was used to detect tyrosine oxidation induced by hydroxyl radicals generated by Fenton reaction (Fe(2+)/H(2)O(2)). Poly(glu, tyr) (4:1) peptides were immobilized on indium tin oxide (ITO) electrode surface via ... |
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Inhibition of lactoperoxidase-catalyzed 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) and tyrosine oxidation by tyrosine-containing random amino acid copolymers.
J. Agric. Food Chem. 56 , 8692-8698, (2008) Oxidation of 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) by lactoperoxidase was found to be inhibited by tyrosine-containing random amino acid copolymers but not by tyrosine. Both electrostatic effects and polymer size were found to be important by ... |
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Chemical rescue of a mutant protein-tyrosine kinase.
J. Biol. Chem. 275 , 38127-38130, (2000) Protein-tyrosine kinases contain a catalytic loop Arg residue located either two or four positions downstream of a highly conserved Asp residue. In this study, the role of this Arg (Arg-318) in the protein-tyrosine kinase C-terminal Src kinase (Csk) was inves... |
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A carboxyl-terminal mutation of the epidermal growth factor receptor alters tyrosine kinase activity and substrate specificity as measured by a fluorescence polarization assay.
J. Biol. Chem. 278 , 26810-26816, (2003) The expression of certain COOH-terminal truncation mutants of the epidermal growth factor receptor (EGFR) can lead to cell transformation, and with ligand stimulation, a broader spectrum of phosphorylated proteins appears compared with EGF-treated cells expre... |
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Comparison of ELISA-based tyrosine kinase assays for screening EGFR inhibitors.
J. Recept. Signal Transduct. Res. 25 , 45-56, (2005) Receptor tyrosine kinases (PTKs) play key roles in the pathogenesis of numerous human diseases, including cancer, and therefore PTK inhibitors are currently under intense investigation as potential drug candidates. PTK inhibitor screening data are, however, p... |
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Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma.
Cancer Res. 60 , 2926, (2000) We determined whether down-regulation of the epidermal growth factor-receptor (EGF-R) signaling pathway by oral administration of a novel EGF-R tyrosine kinase inhibitor (PKI166) alone or in combination with gemcitabine (administered i.p.) can inhibit growth ... |