Echistatin
Echistatin结构式
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常用名 | Echistatin | 英文名 | Echistatin |
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| CAS号 | 154303-05-6 | 分子量 | 5417.0 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C217H341N71O74S9 | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | N/A |
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Biochemical characterization of the binding of echistatin to integrin alphavbeta3 receptor.
J. Pharmacol. Exp. Ther. 283(2) , 843-53, (1997) Echistatin is a 49-amino-acid peptide belonging to the family of disintegrins that are derived from snake venoms and are potent inhibitors of platelet aggregation and cell adhesion. Integrin alphavbeta3 receptor plays a critical role in several physiological ... |
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Vitronectin receptor (alpha(v)beta3) mediates platelet adhesion to the luminal aspect of endothelial cells: implications for reperfusion in acute myocardial infarction.
Circulation 96(6) , 1809-18, (1997) Platelet interaction with endothelium plays an important role in the pathophysiology of coronary microcirculation. We assessed the role of the vitronectin receptor (integrin alpha(v)beta3) in platelet/endothelium adhesion.We investigated the effect on platele... |
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Structural analysis of a biologically active echistatin analogue des(46-49)-[Ala8,37]-echistatin gamma with three disulfide bonds by 2D-NMR and computer graphics.
Biochem. Biophys. Res. Commun. 220(2) , 246-54, (1996) An echistatin analogue, designated as des(46-49)-[Ala8,37]-echistatin gamma, was synthesized chemically by solid-phase peptide synthesis. The analogue was made by replacing Cys8 and Cys37 residues with two alanines and the deletion of C-terminal peptide 46-49... |
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Echistatin. A potent platelet aggregation inhibitor from the venom of the viper, Echis carinatus.
J. Biol. Chem. 263 , 19827-19832, (1988) A 49-residue protein, echistatin, which inhibits platelet aggregation, was purified from the venom of the saw-scaled viper Echis carinatus. The purification procedure included gel filtration on Sephadex G-50, cation-exchange chromatography on Mono S, and C18 ... |
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Echistatin is a potent inhibitor of bone resorption in culture.
J. Cell Biol. 111(4) , 1713-23, (1990) The venom protein, s-echistatin, originally derived from the saw-scaled viper Echis carinatus, was found to be a potent inhibitor of bone resorption by isolated osteoclasts. This Arg24-Gly25-Asp26-(RGD)-containing protein inhibited the excavation of bone slic... |
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Functional analysis of zebrafish microfibril-associated glycoprotein-1 (Magp1) in vivo reveals roles for microfibrils in vascular development and function.
Blood 107(11) , 4364-74, (2006) Mutations in fibrillin-1 (FBN1) result in Marfan syndrome, demonstrating a critical requirement for microfibrils in vessel structure and function. However, the identity and function of many microfibril-associated molecules essential for vascular development a... |
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Imaging tumor angiogenesis with contrast ultrasound and microbubbles targeted to alpha(v)beta3.
Circulation 108(3) , 336-41, (2003) Angiogenesis is a critical determinant of tumor growth and metastasis. We hypothesized that contrast-enhanced ultrasound (CEU) with microbubbles targeted to alpha(v)-integrins expressed on the neovascular endothelium could be used to image angiogenesis.Malign... |
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Functional and computational studies of the ligand-associated metal binding site of beta3 integrins.
Proteins 71 , 1779-91, (2009) A combination of experimental and computational approaches was used to provide a structural context for the role of the beta3 integrin subunit ligand-associated metal binding site (LIMBS) in the binding of physiological ligands to beta3 integrins. Specificall... |