Sauvagine
Sauvagine结构式
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常用名 | Sauvagine | 英文名 | Sauvagine TFA |
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| CAS号 | 74434-59-6 | 分子量 | 3334.68 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C202H346N56O63S | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | N/A |
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Differential activation of CRF receptor subtypes removes stress-induced memory deficit and anxiety.
Eur. J. Neurosci. 25(11) , 3385-97, (2007) The objective of this study was to investigate the role of corticotropin-releasing factor receptors 1 (CRF(1)) and 2 (CRF(2)) in anxiety-like behavior and learning of C57BL/6J mice after exposure to a stressful stimulus. When C57BL/6J mice were exposed to imm... |
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Exploring the binding site crevice of a family B G protein-coupled receptor, the type 1 corticotropin releasing factor receptor.
Mol. Pharmacol. 78(4) , 785-93, (2010) Family B of G protein-coupled receptors (GPCRs) is composed of receptors that bind peptides, such as secretin, glucagon, parathyroid hormone, and corticotropin releasing factor (CRF), which play critical physiological roles. These receptors, like all GPCRs, s... |
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Cardiovascular responses to microinjections of urocortin 3 into the nucleus tractus solitarius of the rat.
Am. J. Physiol. Heart Circ. Physiol. 296(2) , H325-32, (2009) Urocortin 3 (Ucn3) is a new member of the corticotropin-releasing factor (CRF) peptide family and is considered to be a specific and endogenous ligand for CRF type 2 receptors (CRF2Rs). The presence of CRF(2)Rs has been reported in the nucleus tractus solitar... |
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Widespread tissue distribution and diverse functions of corticotropin-releasing factor and related peptides.
Gen. Comp. Endocrinol. 146(1) , 9-18, (2006) Peptides of the corticotropin-releasing factor (CRF) family are expressed throughout the central nervous system (CNS) and in peripheral tissues where they play diverse roles in physiology, behavior, and development. Current data supports the existence of four... |
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Effects of corticotropin-releasing factor 1 receptor antagonism on the hypothalamic-pituitary-adrenal axis of rodents.
J. Pharmacol. Exp. Ther. 341(3) , 672-80, (2012) Corticotropin-releasing factor (CRF) is the major hypothalamic neuropeptide responsible for stimulation of the hypothalamic-pituitary-adrenal axis (HPAA), resulting in the synthesis and release of glucocorticoids from the adrenal cortex. In a recent study, we... |
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Corticotropin-releasing hormone skin signaling is receptor-mediated and is predominant in the sebaceous glands.
Horm. Metab. Res. 39(2) , 166-70, (2007) There is increasing evidence that the sebaceous gland expresses receptors for several neuropeptides and is involved in responses to stress. Among them, corticotropin-releasing hormone (CRH) was currently found to be produced also in the skin. In this study, t... |
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Comparison of CRF-immunoreactive neurons distribution in mouse and rat brains and selective induction of Fos in rat hypothalamic CRF neurons by abdominal surgery.
Brain Res. 1415 , 34-46, (2011) Mice and rats are widely used in stress-related behavioral studies while little is known about the distribution of the stress hormone, corticotropin-releasing factor (CRF) in the mouse brain. We developed and characterized a novel rat/mouse CRF polyclonal ant... |
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Residue 17 of sauvagine cross-links to the first transmembrane domain of corticotropin-releasing factor receptor 1 (CRFR1).
J. Biol. Chem. 283(51) , 35644-51, (2008) Corticotropin-releasing factor receptor 1 (CRFR1) mediates the physiological actions of corticotropin-releasing factor in the anterior pituitary gland and the central nervous system. Using chemical cross-linking we have previously reported that residue 16 of ... |
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Corticotropin-releasing factor receptors induce calcium mobilization through cross-talk with Gq-coupled receptors.
Eur. J. Pharmacol. 642(1-3) , 1-9, (2010) The cross-talk between corticotropin-releasing factor (CRF) and muscarinic receptors was investigated by measuring evoked transient increases in cytosolic calcium concentration. HEK293 cells stably expressing human CRF type 1 (hCRF(1)) and type 2(a) (hCRF(2(a... |
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Cardiovascular responses to microinjections of urocortins into the NTS: role of inotropic glutamate receptors.
Am. J. Physiol. Heart Circ. Physiol. 296(6) , H2022-9, (2009) Urocortin 1 (Ucn1) and urocortin 3 (Ucn3) are new members of the corticotrophin-releasing factor (CRF) peptide family. Ucn1 is a ligand for both the CRF type 1 receptors (CRF(1)Rs) and the CRF type 2 receptors (CRF(2)Rs), whereas Ucn3 is a high-affinity ligan... |