阿朴色氨酸酶
阿朴色氨酸酶结构式
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常用名 | 阿朴色氨酸酶 | 英文名 | Tryptophanase |
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| CAS号 | 9024-00-4 | 分子量 | 268.223 | |
| 密度 | 1.7±0.1 g/cm3 | 沸点 | N/A | |
| 分子式 | C11H12N2O6 | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | N/A |
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Inhibition of Escherichia coli tryptophan indole-lyase by tryptophan homologues.
Arch. Biochem. Biophys. 560 , 20-6, (2014) We have designed, synthesized and evaluated homotryptophan analogues as possible mechanism-based inhibitors for Escherichia coli tryptophan indole-lyase (tryptophanase, TIL, E.C. 4.1.99.1). As a quinonoid structure is an intermediate in the reaction mechanism... |
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Reaction pathway of tryptophanase-catalyzed L-tryptophan synthesis from D-serine.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 879(29) , 3289-95, (2011) Tryptophanase, L-tryptophan indole-lyase with extremely absolute stereospecificity, can change the stereospecificity in concentrated diammonium hydrogenphosphate solution. While tryptophanase is not inert to D-serine in the absence of diammonium hydrogenphosp... |
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Indole production by the tryptophanase TnaA in Escherichia coli is determined by the amount of exogenous tryptophan.
Microbiology 159(Pt 2) , 402-10, (2013) The signalling molecule indole occurs in significant amounts in the mammalian intestinal tract and regulates diverse microbial processes, including bacterial motility, biofilm formation, antibiotic resistance and host cell invasion. In Escherichia coli, the e... |
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Properties of tryptophanase from Escherichia coli.
Biochim. Biophys. Acta 65 , 233-44, (1962)
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Antibiotics promoting oxidative stress inhibit formation ofEscherichia colibiofilm via indole signalling
Res. Microbiol. 161(10) , 847-53, (2010) Recent studies have revealed that antibiotics can promote the formation of reactive oxygen species which contribute to cell death. In this study, we report that five different antibiotics known to stimulate production of reactive oxygen species inhibited grow... |
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Efficacy of Lactic Acid Bacteria (LAB) supplement in management of constipation among nursing home residents.
Nutr. J. 9 , 5, (2010) Constipation is a significant problem in the elderly, specifically nursing home and/or extended-care facility residents are reported to suffer from constipation. Lactic acid bacteria (LAB) are beneficial probiotic organisms that contribute to improved nutriti... |
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An in vivo method for characterization of protein interactions within sulfur trafficking systems of E. coli.
J. Proteome Res. 9(12) , 6740-51, (2010) Sulfur trafficking systems are multiprotein systems that synthesize sulfur-containing cofactors such as iron-sulfur clusters. The sulfur is derived enzymatically from cysteine and transferred between nucleophilic cysteine residues within proteins until incorp... |
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CsrA and TnaB coregulate tryptophanase activity to promote exotoxin-induced killing of Caenorhabditis elegans by enteropathogenic Escherichia coli.
J. Bacteriol. 193(17) , 4516-22, (2011) Enteropathogenic Escherichia coli(EPEC) requires the tnaA-encoded enzyme tryptophanase and its substrate tryptophan to synthesize diffusible exotoxins that kill the nematode Caenorhabditis elegans. Here, we demonstrate that the RNA-binding protein CsrA and th... |
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Evidence of preorganization in quinonoid intermediate formation from L-Trp in H463F mutant Escherichia coli tryptophan indole-lyase from effects of pressure and pH.
Biochemistry 51(33) , 6527-33, (2012) The effects of pH and hydrostatic pressure on the reaction of H463F tryptophan indole-lyase (TIL) have been evaluated. The mutant TIL shows very low activity for elimination of indole but is still competent to form a quinonoid intermediate from l-tryptophan [... |
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Benzimidazole analogs of (L)-tryptophan are substrates and inhibitors of tryptophan indole lyase from Escherichia coli.
FEBS J. 280(8) , 1807-17, (2013) Tryptophan indole lyase (TIL), an enzyme found in Escherichia coli and related enterobacteria, produces indole from l-tryptophan (l-Trp). Indole is a signaling molecule in bacteria, affecting biofilm formation, pathogenicity and antibiotic resistance. β-(Benz... |