α1-酸性糖蛋白 来源于人类血浆
α1-酸性糖蛋白 来源于人类血浆结构式
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常用名 | α1-酸性糖蛋白 来源于人类血浆 | 英文名 | α1-Acid Glycoprotein, from human plasma |
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| CAS号 | 66455-27-4 | 分子量 | N/A | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | N/A | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | N/A |
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Protein-bound polysaccharide decreases invasiveness and proliferation in pancreatic cancer by inhibition of hedgehog signaling and HIF-1α pathways under hypoxia.
Cancer Lett. 335(2) , 289-98, (2013) To develop an effective therapeutic approach to pancreatic ductal adenocarcinoma (PDAC), we focused on the antitumor mechanism of protein-bound polysaccharide (PSK) under hypoxia. PSK decreased proliferation in PDAC cells under hypoxia but not normoxia. PSK a... |
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Biological mechanism and clinical effect of protein-bound polysaccharide K (KRESTIN(®)): review of development and future perspectives.
Surg. Today 42(1) , 8-28, (2012) The mechanism of action of protein-bound polysaccharide K (PSK; KRESTIN(®)) involves the following actions: (1) recovery from immunosuppression induced by humoral factors such as transforming growth factor (TGF)-β or as a result of surgery and chemotherapy; (... |
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Direct inhibition of the transforming growth factor-β pathway by protein-bound polysaccharide through inactivation of Smad2 signaling.
Cancer Sci. 103(2) , 317-24, (2012) Transforming growth factor-β (TGF-β) is involved in the regulation of cell proliferation, differentiation, and apoptosis and is associated with epithelial-mesenchymal transition (EMT). Inhibition of the TGF-β pathway is an attractive strategy for the treatmen... |
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Immunotherapy eradicates metastases with reversible defects in MHC class I expression.
Cancer Immunol. Immunother. 60(9) , 1257-68, (2011) Tumor or metastatic cells lose MHC class I (MHC-I) expression during cancer progression as an escape mechanism from immune surveillance. These defects in MHC-I may be reversible by cytokines or different agents (soft lesions) or irreversible due to structural... |
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Polysaccharide-K (PSK) may suppress surgical stress-induced metastasis in rat colon cancer.
Langenbecks. Arch. Surg. 397(3) , 475-80, (2012) We previously demonstrated that hepatic ischemia and reperfusion (I/R) injury increased liver metastasis and cancer growth of RCN-H4 cells. Using a rat model of hepatic I/R-induced liver metastasis, we investigated the metastasis-suppressing effect of polysac... |
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Polysaccharide-K augments docetaxel-induced tumor suppression and antitumor immune response in an immunocompetent murine model of human prostate cancer.
Int. J. Oncol. 40(4) , 905-13, (2012) Advanced castration-resistant prostate cancer has high mortality rates and limited treatment options. Novel therapies are needed to better contend with this disease. Polysaccharide-K® (PSK), an extract of the mushroom Trametes versicolor, has immunomodulatory... |
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Protein-bound polysaccharide-K (PSK) induces apoptosis via p38 mitogen-activated protein kinase pathway in promyelomonocytic leukemia HL-60 cells.
Anticancer Res. 32(7) , 2631-7, (2012) Protein-bound polysaccharide-K (PSK) is extracted from Coriolus versicolor (CM101) and is clinically used in combination therapy for gastrointestinal cancer and small-cell lung carcinoma. We have previously demonstrated that PSK induces apoptosis and inhibite... |
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PSK induces apoptosis through the inhibition of activated STAT3 in human esophageal carcinoma cells.
Int. J. Oncol. 41(1) , 61-6, (2012) PSK, a protein-bound polysaccharide, is widely used in Japan as an immunopotentiating biological response modifier for cancer patients. PSK exerts antitumor activities through stimulation of the host's immune response; however, few studies have addressed the ... |
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Nutrition in oncologic patients during antiblastic treatment.
Front. Biosci. (Landmark Ed.) 18 , 120-32, (2013) Cancer may induce weight loss and cachexia, and cancer treatment may contribute to nutritional impairment. Here, we review the literature on the mechanisms of cancer cachexia and the pharmacological interventions both in use in clinical practice and currently... |
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The expression of integrins is decreased in colon cancer cells treated with polysaccharide K.
Int. J. Oncol. 42(4) , 1175-80, (2013) Polysaccharide K (PSK), a protein-bound polysaccharide used as a non-specific immunotherapeutic agent, is said to improve the prognosis of malignant tumors such as colon cancer, but there have been few in‑depth investigations of its mechanism of action. In th... |