胰岛素(人)
胰岛素(人)结构式
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常用名 | 胰岛素(人) | 英文名 | Insulin(human) |
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| CAS号 | 11061-68-0 | 分子量 | 5807.58 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C257H383N65O77S6 | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | N/A |
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Intracellular Ca(2+)-handling differs markedly between intact human muscle fibers and myotubes.
Skelet. Muscle 5 , 26, (2015) In skeletal muscle, intracellular Ca(2+) is an important regulator of contraction as well as gene expression and metabolic processes. Because of the difficulties to obtain intact human muscle fibers, human myotubes have been extensively employed for studies o... |
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LipiD-QuanT: a novel method to quantify lipid accumulation in live cells.
J. Lipid Res. 56 , 2206-16, (2015) Lipid droplets (LDs) are the main storage organelles for triglycerides. Elucidation of lipid accumulation mechanisms and metabolism are essential to understand obesity and associated diseases. Adipogenesis has been well studied in murine 3T3-L1 and human Simp... |
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Autophagosome-lysosome fusion is independent of V-ATPase-mediated acidification.
Nat. Commun. 6 , 7007, (2015) The ATP-dependent proton pump V-ATPase ensures low intralysosomal pH, which is essential for lysosomal hydrolase activity. Based on studies with the V-ATPase inhibitor BafilomycinA1, lysosomal acidification is also thought to be required for fusion with incom... |
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Differential Effects of Tissue-Specific Deletion of BOSS on Feeding Behaviors and Energy Metabolism.
PLoS ONE 10 , e0133083, (2015) Food intake and energy metabolism are tightly controlled to maintain stable energy homeostasis and healthy states. Thus, animals detect their stored energy levels, and based on this, they determine appropriate food intake and meal size. Drosophila melanogaste... |
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Epigenetic silencing of Oct4 by a complex containing SUV39H1 and Oct4 pseudogene lncRNA.
Nat. Commun. 6 , 7631, (2015) Pseudogene-derived, long non-coding RNAs (lncRNAs) act as epigenetic regulators of gene expression. Here we present a panel of new mouse Oct4 pseudogenes and demonstrate that the X-linked Oct4 pseudogene Oct4P4 critically impacts mouse embryonic stem cells (m... |
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Functional microRNA library screening identifies the hypoxamir miR-24 as a potent regulator of smooth muscle cell proliferation and vascularization.
Antioxid. Redox Signal. 21(8) , 1167-76, (2014) Smooth muscle cells (SMCs) are key components within the vasculature. Dependent on the stimulus, SMC can either be in a proliferative (synthetic) or differentiated state. Alterations of SMC phenotype also appear in several disease settings, further contributi... |
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The Prion Protein Controls Polysialylation of Neural Cell Adhesion Molecule 1 during Cellular Morphogenesis.
PLoS ONE 10 , e0133741, (2015) Despite its multi-faceted role in neurodegenerative diseases, the physiological function of the prion protein (PrP) has remained elusive. On the basis of its evolutionary relationship to ZIP metal ion transporters, we considered that PrP may contribute to the... |
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Sodium butyrate epigenetically modulates high-fat diet-induced skeletal muscle mitochondrial adaptation, obesity and insulin resistance through nucleosome positioning.
Br. J. Pharmacol. 172 , 2782-98, (2015) Sodium butyrate (NaB), an epigenetic modifier, is effective in promoting insulin sensitivity. The specific genomic loci and mechanisms underlying epigenetically induced obesity and insulin resistance and the targets of NaB are not fully understood.The anti-di... |
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Differential expressions of adhesive molecules and proteases define mechanisms of ovarian tumor cell matrix penetration/invasion.
PLoS ONE 6 , e18872, (2011) Epithelial ovarian cancer is an aggressive and deadly disease and understanding its invasion mechanisms is critical for its treatment. We sought to study the penetration/invasion of ovarian tumor cells into extracellular matrices (ECMs) using a fibroblast-der... |
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GH action influences adipogenesis of mouse adipose tissue-derived mesenchymal stem cells.
J. Endocrinol. 226 , 13-23, (2015) GH influences adipocyte differentiation, but both stimulatory and inhibitory effects have been described. Adipose tissue-derived mesenchymal stem cells (AT-MSCs) are multipotent and are able to differentiate into adipocytes, among other cells. Canonical Wnt/β... |