西潘茶碱
西潘茶碱结构式
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常用名 | 西潘茶碱 | 英文名 | Cipamfylline |
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| CAS号 | 132210-43-6 | 分子量 | 275.30600 | |
| 密度 | 1.538g/cm3 | 沸点 | 555.2ºC at 760mmHg | |
| 分子式 | C13H17N5O2 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 289.6ºC |
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Beneficial effects of the phosphodiesterase inhibitors BRL 61063, pentoxifylline, and rolipram in a murine model of endotoxin shock.
Circ. Shock. 44(4) , 188-95, (1994) Three inhibitors of calcium-dependent cyclic adenosine 3'5'-monophosphate (cAMP) dependent phosphodiesterase IV (PDE IV) were evaluated for their effects on lipopolysaccharide (LPS)-induced tumor necrosis factor (TNF) production in vitro and in vivo and for t... |
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Stimulation of the hypothalamo-pituitary-adrenal axis in the rat by three selective type-4 phosphodiesterase inhibitors: in vitro and in vivo studies.
Br. J. Pharmacol. 121(3) , 459-68, (1997) 1. Previous studies in our laboratory have shown that the synthetic xanthine analogue denbufylline, a selective type 4 phosphodiesterase (PDE-4) inhibitor, is a potent activator of the hypothalamo-pituitary-adrenal (HPA) axis when given orally or intraperiton... |
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Identification, characterization, and functional role of phosphodiesterase type IV in cerebral vessels: effects of selective phosphodiesterase inhibitors.
J. Cereb. Blood Flow Metab. 17(2) , 210-9, (1997) The role of the phosphodiesterase type IV isozyme (PDE IV) in the regulation of cerebrovascular tone was investigated in the canine basilar artery in vitro and in vivo. The PDE isozymes extracted from the canine basilar artery were isolated by diethylaminoeth... |
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Inhibition of cyclic nucleotide phosphodiesterase by derivatives of 1,3-bis(cyclopropylmethyl)xanthine.
J. Med. Chem. 37(4) , 476-85, (1994) Alkylation of the selective type IV phosphodiesterase inhibitor, 8-amino-1,3-bis(cyclopropylmethyl)-xanthine (1, BRL 61063), led exclusively to the N-7 substituted derivatives 2-9, which showed varying selectivities for the PDE type IV isoenzyme relative to P... |
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Theoretical and experimental investigations on the morphology of pharmaceutical crystals.
J. Pharm. Sci. 91(7) , 1652-8, (2002) We investigated the morphologies of three polymorphs of 1,3-di(cyclopropylmethyl)-8-aminoxanthine, a compound of pharmaceutical importance. We compared the experimental morphologies with those predicted by theoretical methods. We also predicted the elastic co... |
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Effect of TNF alpha production inhibitors BRL 61063 and pentoxifylline on the response of rats to poly I:C.
Toxicology 95(1-3) , 187-96, (1995) BRL 61063 is a novel xanthine phosphodiesterase (PDE) type IV inhibitor with selective inhibitory activity for tumor necrosis factor (TNF) alpha production. This compound inhibits TNF alpha production by activated human blood monocytes in vitro and in animal ... |