阿托西班
阿托西班结构式
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常用名 | 阿托西班 | 英文名 | (Deamino-Cys1,D-Tyr(Et)2,Thr4,Orn8)-Oxytocin acetate salt |
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| CAS号 | 90779-69-4 | 分子量 | 994.189 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 1469.0±65.0 °C at 760 mmHg | |
| 分子式 | C43H67N11O12S2 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 842.2±34.3 °C |
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Reversal of peripheral nerve injury-induced hypersensitivity in the postpartum period: role of spinal oxytocin.
Anesthesiology 118(1) , 152-9, (2013) Physical injury, including surgery, can result in chronic pain; yet chronic pain following childbirth, including cesarean delivery in women, is rare. The mechanisms involved in this protection by pregnancy or delivery have not been explored.We examined the ef... |
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Development and clinical experience with the new evidence-based tocolytic atosiban.
Acta Obstet. Gynecol. Scand. 81(7) , 633-41, (2002) The incidence of preterm birth has remained unchanged for the last few decades. This is due, in part, to the complex etiology of preterm labor, and the limited ability of tocolytic agents to prolong pregnancy as a result of limited efficacy and poor safety pr... |
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Oxytocin regulates changes of extracellular glutamate and GABA levels induced by methamphetamine in the mouse brain.
Addict. Biol. 17(4) , 758-69, (2012) Oxytocin (OT), a neurohypophyseal neuropeptide, affects adaptive processes of the central nervous system. In the present study, we investigated the effects of OT on extracellular levels of glutamate (Glu) and γ-aminobutyric acid (GABA) induced by methamphetam... |
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Treatment of preterm labor with the oxytocin and vasopressin antagonist Atosiban.
J. Perinat. Med. 26(6) , 458-65, (1998) Oxytocin is involved in the regulation of preterm and term labor but the exact effect mechanisms are not fully understood. A regulatory action by vasopressin may also exist. The concentrations of oxytocin and vasopressin V1a receptors in myometrium from pregn... |
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Oxytocin inhibits the membrane depolarization-induced increase in intracellular calcium in capsaicin sensitive sensory neurons: a peripheral mechanism of analgesic action.
Anesth. Analg. 114(2) , 442-9, (2012) Lumbar intrathecal injection of oxytocin produces antinociception in rats and analgesia in humans. Classically, oxytocin receptors couple to stimulatory G proteins, increase inositol-3-phosphate production, and result in neuronal excitation. Most work to date... |
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Effectiveness of nifedipine versus atosiban for tocolysis in preterm labour: a meta-analysis with an indirect comparison of randomised trials.
BJOG 110(12) , 1045-9, (2003) To explore the effectiveness of nifedipine compared with atosiban for tocolysis in preterm labour.A systematic review of randomised controlled trials with meta-analysis using adjusted indirect comparison.Six hundred and seventy-nine women recruited in nine ra... |
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Atosiban versus betamimetics in the treatment of preterm labour in Italy: clinical and economic importance of side-effects.
Eur. J. Obstet. Gynecol. Reprod. Biol. 157(2) , 128-35, (2011) The aim of this study was to determine the cost effectiveness of atosiban compared to betamimetics in the treatment of preterm labour within the Italian setting. A systematic literature review identified randomised controlled trials (RCTs) comparing atosiban ... |
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Is preconditioning by oxytocin administration mediated by iNOS and/or mitochondrial K(ATP) channel activation in the in vivo anesthetized rabbit heart?
Life Sci. 90(19-20) , 763-9, (2012) Oxytocin (OXT) pretreatment protects the heart during ischemia-reperfusion injury by activating ATP-dependent potassium (K(ATP)) channels. The aim of the current study was to elucidate the roles of nitric oxide synthaseNOS and myocardial biochemistry in the c... |
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Atosiban versus betamimetics in the treatment of preterm labour in Germany: an economic evaluation.
BMC Pregnancy Childbirth 9 , 23, (2009) The use of tocolytics is central in delaying birth; however, therapeutic options vary in effectiveness and adverse events profiles, which in turn could have consequences for medical resource use and cost of treatment. Betamimetics are commonly used tocolytic ... |
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The effect of acute stress exposure on ischemia and reperfusion injury in rat heart: role of oxytocin.
Stress 15(4) , 385-92, (2012) Previous studies showed the protective effects of oxytocin (OT) on myocardial injury in ischemic and reperfused rat heart. Moreover, exposure to various stressors not only evokes sudden cardiovascular effects but also triggers the release of OT in the rat. Th... |