二肽基肽酶 IV
二肽基肽酶 IV结构式
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常用名 | 二肽基肽酶 IV | 英文名 | Dipeptidylpeptidase IV |
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| CAS号 | 54249-88-6 | 分子量 | N/A | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | N/A | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | N/A |
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The SUMO1-E67 interacting loop peptide is an allosteric inhibitor of the dipeptidyl peptidases 8 and 9.
J. Biol. Chem. 288(45) , 32787-96, (2013) The intracellular peptidases dipeptidyl peptidase (DPP) 8 and DPP9 are involved in multiple cellular pathways including antigen maturation, cellular homeostasis, energy metabolism, and cell viability. Previously we showed that the small ubiquitin-like protein... |
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Adenosine deaminase acts as a natural antagonist for dipeptidyl peptidase 4-mediated entry of the Middle East respiratory syndrome coronavirus.
J. Virol. 88(3) , 1834-8, (2014) Middle East respiratory syndrome coronavirus (MERS-CoV) replicates in cells of different species using dipeptidyl peptidase 4 (DPP4) as a functional receptor. Here we show the resistance of ferrets to MERS-CoV infection and inability of ferret DDP4 to bind ME... |
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Vildagliptin ameliorates oxidative stress and pancreatic beta cell destruction in type 1 diabetic rats.
Arch. Med. Res. 44(3) , 194-202, (2013) It is believed that oxidative stress plays a role in the pathogenesis of diabetes mellitus. Several strategies have been developed with the objective of minimizing diabetic complications. Among these, inhibitors of dipeptidyl peptidase-IV (DPP-IV), which act ... |
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Identification of altered dipeptidyl-peptidase activities as potential biomarkers for unipolar depression.
J. Affect. Disord. 151(2) , 667-72, (2013) Changes in circulatory aminopeptidases [dipeptidyl-peptidase-IV (DPP-IV), Prolyl-oligopeptidase (POP) and Leucine aminopeptidase (LAP)] activities have been found to be associated with psychiatric illnesses and inflammatory diseases.The discriminatory indices... |
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Biological evaluation of RBx-0128, a potent and selective dipeptidyl peptidase-IV inhibitor in type 2 diabetes genetic model.
Indian J. Pharmacol. 44(6) , 759-64, (2012) Dipeptidyl peptidase IV (DPP-IV) inhibition to modulate the incretin effect is a proven strategy to treat type 2 diabetes mellitus. The present study describes the pharmacological profile of a novel DPP-IV inhibitor RBx-0128, as an antidiabetic agent.DPP-IV a... |
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Beyond insulin: what else might help?
Diabetes Self. Manag. 31(1) , 30, 32-4, (2014)
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MERS coronovirus has probably been present in bats for many years, research shows.
BMJ 347 , f6141, (2013)
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The relationship between anagliptin concentration showing over 80% inhibition of plasma dipeptidyl peptidase-4 activity and its protective effect against glucagon-like peptide-1 degradation.
Drug Res. (Stuttg.) 64(3) , 130-5, (2014) In dipeptidyl peptidase-4 (DPP-4) inhibitors, the inhibition of plasma DPP-4 activity by 80% is considered sufficient to have an effect on glycemic control improvement through the elevation of intact glucagon-like peptide-1 (GLP-1). To clarify whether or not ... |
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[Antibody therapy for malignant mesothelioma: humanized anti-cD26 mAb therapy].
Nihon Rinsho. 70(12) , 2177-82, (2012) Malignant mesothelioma (MM) is an aggressive malignancy arising from the mesothelial cells. It is generally associated with a history of asbestos exposure and has a very poor prognosis. Due to lack of efficacy of conventional treatments, novel therapeutic str... |
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[109th Scientific Meeting of the Japanese Society of Internal Medicine: educational lecture: 9. Incretin-based therapy for type 2 diabetes mellitus].
Nippon. Naika Gakkai Zasshi. 101(9) , 2698-705, (2012)
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