缩胆囊素
缩胆囊素结构式
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常用名 | 缩胆囊素 | 英文名 | Cholecystokinin |
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| CAS号 | 9011-97-6 | 分子量 | 3931.41903999997 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C166H261N51O52S4 | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | N/A |
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ERK activation is required for CCK-mediated pancreatic adaptive growth in mice.
Am. J. Physiol. Gastrointest. Liver Physiol. 307(7) , G700-10, (2014) High levels of cholecystokinin (CCK) can stimulate pancreatic adaptive growth in which mature acinar cells divide, leading to enhanced pancreatic mass with parallel increases in protein, DNA, RNA, and digestive enzyme content. Prolonged release of CCK can be ... |
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Concurrent modulation of extracellular levels of noradrenaline and cAMP during stress and by anxiogenic- or anxiolytic-like neuropeptides in the prefrontal cortex of awake rats.
Neurochem. Int. 62(3) , 314-23, (2013) The purpose of this study was to examine the effects of stress and the role of locally infused anxiogenic-like neuropeptides galanin, CCK-8, vasopressin, substance P and neurokinin A, and anxiolytic-like peptides NPY, nociceptin/orphanin FQ, somatostatin and ... |
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Increased nutrient sensitivity and plasma concentrations of enteral hormones during duodenal nutrient infusion in functional dyspepsia.
Am. J. Gastroenterol. 109(12) , 1910-20; quiz 1909, 1921, (2014) Functional dyspepsia is predominantly attributed to gastric sensorimotor dysfunctions. The contribution of intestinal chemosensitivity to symptoms is not understood. We evaluated symptoms and plasma hormones during enteral nutrient infusion and the associatio... |
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Up-regulation of cholesterol absorption is a mechanism for cholecystokinin-induced hypercholesterolemia.
J. Biol. Chem. 289(19) , 12989-99, (2014) Excessive absorption of intestinal cholesterol is a risk factor for atherosclerosis. This report examines the effect of cholecystokinin (CCK) on plasma cholesterol level and intestinal cholesterol absorption using the in vivo models of C57BL/6 wild-type and l... |
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Dual origins of functionally distinct O-LM interneurons revealed by differential 5-HT(3A)R expression.
Nat. Neurosci. 16(11) , 1598-607, (2013) Forebrain circuits rely upon a relatively small but remarkably diverse population of GABAergic interneurons to bind and entrain large principal cell assemblies for network synchronization and rhythmogenesis. Despite the high degree of heterogeneity across cor... |
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Apamin attenuated cerulein-induced acute pancreatitis by inhibition of JNK pathway in mice.
Dig. Dis. Sci. 58(10) , 2908-17, (2013) We have previously reported that bee venom (BV) has a protective role against acute pancreatitis (AP). However, the effects of apamin, the major compound of BV, on AP have not been determined. The aim of this study was to evaluate the effects of apamin on cer... |
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Serotonin and cholecystokinin mediate nutrient-induced segmentation in guinea pig small intestine.
Am. J. Physiol. Gastrointest. Liver Physiol. 304(8) , G749-61, (2013) Segmentation is an important process in nutrient mixing and absorption; however, the mechanisms underlying this motility pattern are poorly understood. Segmentation can be induced by luminal perfusion of fatty acid in guinea pig small intestine in vitro and m... |
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Role of peptide YY(3-36) in the satiety produced by gastric delivery of macronutrients in rats.
Am. J. Physiol. Endocrinol. Metab. 304(9) , E944-50, (2013) Peptide YY(3-36) [PYY(3-36)] is postulated to act as a hormonal signal from gut to brain to inhibit food intake. PYY(3-36) potently reduces food intake when administered systemically or into the brain. If action of endogenous PYY(3-36) is necessary for normal... |
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GABA(B) autoreceptor-mediated cell type-specific reduction of inhibition in epileptic mice.
Proc. Natl. Acad. Sci. U. S. A. 110(37) , 15073-8, (2013) GABA(B) receptors (GABA(B)Rs) mediate slow inhibitory effects on neuronal excitability and synaptic transmission in the brain. However, the GABA(B)R agonist baclofen can also promote excitability and seizure generation in human patients and animals models. He... |
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Gastrointestinal dysmotility: evidence and clinical management.
Curr. Opin. Clin. Nutr. Metab. Care 16(2) , 209-16, (2013) Gastrointestinal dysmotility and dysfunction underlie our difficulties in providing adequate nutrition by the enteral route to our critically ill patients.Recent studies have quantified gastric emptying and nutrient absorption. Slow gastric emptying is common... |