D-氨基酸氧化酶 来源于猪肾
D-氨基酸氧化酶 来源于猪肾结构式
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常用名 | D-氨基酸氧化酶 来源于猪肾 | 英文名 | D-Amino acid oxidase |
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| CAS号 | 9000-88-8 | 分子量 | N/A | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C9H20N2O2 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | N/A |
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Add-on treatment of benzoate for schizophrenia: a randomized, double-blind, placebo-controlled trial of D-amino acid oxidase inhibitor.
JAMA Psychiatry 70(12) , 1267-75, (2013) In addition to dopaminergic hyperactivity, hypofunction of the N-methyl-d-aspartate receptor (NMDAR) has an important role in the pathophysiology of schizophrenia. Enhancing NMDAR-mediated neurotransmission is considered a novel treatment approach. To date, s... |
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D-Amino acids in the brain and mutant rodents lacking D-amino-acid oxidase activity.
Amino Acids 43(5) , 1811-21, (2012) D-Amino acids are stereoisomers of L-amino acids. They are often called unnatural amino acids, but several D-amino acids have been found in mammalian brains. Among them, D-serine is abundant in the forebrain and functions as a co-agonist of NMDA receptors to ... |
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Brain D-amino acids: a novel class of neuromodulators.
Amino Acids 43(5) , 1809-10, (2012)
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D-Amino acids in brain neurotransmission and synaptic plasticity.
Amino Acids 43(5) , 1851-60, (2012) Far from our initial view of D-amino acids as being limited to invertebrates, they are now considered active molecules at synapses of mammalian central and peripheral nervous systems, capable of modulating synaptic communication within neuronal networks. In p... |
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Structural, kinetic, and pharmacodynamic mechanisms of D-amino acid oxidase inhibition by small molecules.
J. Med. Chem. 56(9) , 3710-24, (2013) We characterized the mechanism and pharmacodynamics of five structurally distinct inhibitors of d-amino acid oxidase. All inhibitors bound the oxidized form of human enzyme with affinity slightly higher than that of benzoate (Kd ≈ 2-4 μM). Stopped-flow experi... |
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4-Hydroxypyridazin-3(2H)-one derivatives as novel D-amino acid oxidase inhibitors.
J. Med. Chem. 56(9) , 3582-92, (2013) D-Amino acid oxidase (DAAO) catalyzes the oxidation of d-amino acids including d-serine, a coagonist of the N-methyl-d-aspartate receptor. We identified a series of 4-hydroxypyridazin-3(2H)-one derivatives as novel DAAO inhibitors with high potency and substa... |
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Astrocytes are involved in trigeminal dynamic mechanical allodynia: potential role of D-serine.
J. Dent. Res. 92(9) , 808-13, (2013) Trigeminal neuropathic pain affects millions of people worldwide. Despite decades of study on the neuronal processing of pain, mechanisms underlying enhanced pain states after injury remain unclear. N-methyl-D-aspartate (NMDA) receptor-dependent changes play ... |
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Characterization of human DAAO variants potentially related to an increased risk of schizophrenia.
Biochim. Biophys. Acta 1832(3) , 400-10, (2013) Considering the key role of d-serine in N-methyl-d-aspartate receptor-mediated neurotransmission, it is highly relevant to define the role that enzymes play in d-serine synthesis and degradation. In particular, the details of regulation of the d-serine catabo... |
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Amperometric microbiosensor as an alternative tool for investigation of D-serine in brain.
Amino Acids 43(5) , 1887-94, (2012) This paper discusses the application of a reagentless, selective microbiosensor as a useful alternative tool for monitoring D-serine in neural samples. The main components of the 125-μm-diameter disk biosensor were D-amino acid oxidase for D-serine sensitivit... |
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Fluorimetric assay for D-amino acid oxidase activity in rat brain homogenate by using D-kynurenine as a substrate.
Biosci. Trends 6(5) , 241-7, (2012) An easy fluorimetric assay for measuring D-amino acid oxidase (DAAO) activity by using one of the D-amino acids--D-kynurenine (D-KYN)--as a substrate was applied to assess DAAO activity in the cerebrum, cerebellum, and brainstem of Sprague-Dawley (SD) male ra... |