乙去氧尿啶
乙去氧尿啶结构式
|
常用名 | 乙去氧尿啶 | 英文名 | Edoxudine |
|---|---|---|---|---|
| CAS号 | 15176-29-1 | 分子量 | 256.25500 | |
| 密度 | 1.389 g/cm3 | 沸点 | N/A | |
| 分子式 | C11H16N2O5 | 熔点 | 152-153° | |
| MSDS | 美版 | 闪点 | N/A |
|
Sensitivity of monkey B virus (Cercopithecine herpesvirus 1) to antiviral drugs: role of thymidine kinase in antiviral activities of substrate analogs and acyclonucleosides.
Antimicrob. Agents Chemother. 51 , 2028-34, (2007) Herpes B virus (B virus [BV]) is a macaque herpesvirus that is occasionally transmitted to humans where it can cause rapidly ascending encephalitis that is often fatal. To understand the low susceptibility of BV to the acyclonucleosides, we have cloned, expre... |
|
|
Pleiotrophin suppression of receptor protein tyrosine phosphatase-β/ζ maintains the self-renewal competence of fetal human oligodendrocyte progenitor cells.
J. Neurosci. 32(43) , 15066-75, (2012) Oligodendrocyte progenitor cells (OPCs) persist in human white matter, yet the mechanisms by which they are maintained in an undifferentiated state are unknown. Human OPCs differentially express protein tyrosine phosphatase receptor β/ζ (PTPRZ1) and its inhib... |
|
|
An in vitro study of ophthalmic antiviral agent toxicity on rabbit corneal epithelium.
Antiviral Res. 9(4) , 263-72, (1988) Using an in vitro system we measured the corneal epithelial cytotoxicity and the antiviral activity of the antiviral agents idoxuridine (IDU), trifluridine (TFT), ethyldeoxyuridine (EDU), and (E)-5-(2-Bromovinyl)-2'-deoxyuridine (BVDU). Confluent rabbit corne... |
|
|
Accumulation of 5-ethyl-2'-deoxyuridine and its 5,6-dihydro prodrugs in murine lung and its potential clinical application.
J. Pharm. Pharmacol. 47(7) , 595-600, (1995) The accumulation of 5-ethyl-2'-deoxyuridine (EDU), (--)-trans-(5S,6S)-5-bromo-5-ethyl-6-methoxy-5,6- dihydro-2'-deoxyuridine [(5S,6S)-BMEDU], (+)-trans-(5R,6R) -5-bromo-ethyl-6-methoxy-5,6-dihydro- 2'-deoxyuridine [(5R,6R)-BMEDU], (+)-trans-(5R,6R)-5-bromo- 5... |
|
|
[Metabolic studies of 5-ethyl-2'-deoxyuridine with liver extract, liver cells and liver cell culture].
Arzneimittelforschung 39(2) , 220-2, (1989) 5-Ethyl-2'-deoxyuridine (EtUdR) was converted with rat liver extract, rat liver cells and rat liver cell cultures into its metabolites 5-ethyluracil and 5-(1-hydroxyethyl) uracil. The analytical identification of the metabolites as well as the investigation o... |
|
|
Retinal toxicity of intravitreal ethyldeoxyuridine and zinc.
Ann. Ophthalmol. 20(10) , 385-7, (1988) We investigated the toxicity of intravitreal zinc sulfate, zinc gluconate, and ethyldeoxyuridine (EDU) in albino rabbits. Various concentrations of EDU were added to the infusion solution during pars plana vitrectomy. Retinal changes were observed by light mi... |
|
|
5-Ethyl-2'-deoxyuridine: an explanation for its lack of cytotoxic action in vivo.
Eur. J. Cancer Clin. Oncol. 22(5) , 557-62, (1986) The aim of this study was to explain why 5-ethyldeoxyuridine (EUdR) showed cytotoxic activity against Ehrlich ascites tumour (EAT) cells in vitro but not in vivo. In vitro studies showed that EUdR was phosphorylated to nucleotides which inhibit thymidylate sy... |
|
|
High-performance liquid chromatographic analysis of 5-ethylpyrimidines and 5-methylpyrimidines in plasma.
J. Chromatogr. A. 563(2) , 392-9, (1991) A high-performance liquid chromatographic (HPLC) method employing a C18 reversed-phase column, a mobile phase of sodium acetate and methanol, and an ultraviolet detector was developed for the analysis of 5-ethylpyrimidines and 5-methylpyrimidines in plasma. S... |
|
|
5-Hexyl-2'-deoxyuridine blocks the cytotoxic effects of 5-fluorodeoxyuridine or deoxyadenosine in leukemia L1210 cells in culture.
Cancer Res. 50(15) , 4552-6, (1990) Antitumor agents which block the de novo synthesis of nucleotides can be circumvented by the presence of salvage pathways for the reutilization of nucleobases and nucleosides. Studies have been carried out which show that 5-hexyl-2'-deoxyuridine (HdUrd) effec... |
|
|
Elimination of the antiviral drug 5-ethyl-2'-deoxyuridine by the isolated perfused rat liver.
Drug Metab. Dispos. 19(6) , 1058-65, (1991) The elimination of the antiviral drug 5-ethyl-2'-deoxyuridine (EdUrd) by the isolated perfused rat liver was investigated. EdUrd (3.9-39 mumol) was injected into the perfusion reservoir and serial samples were collected for HPLC determination of EdUrd and its... |