棕榈酰-CYS((RS)-2,3-二(棕榈酰氧基)-丙基)-OH
棕榈酰-CYS((RS)-2,3-二(棕榈酰氧基)-丙基)-OH结构式
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常用名 | 棕榈酰-CYS((RS)-2,3-二(棕榈酰氧基)-丙基)-OH | 英文名 | N-ALPHA-PALMITOYL-S-[2,3-BIS(PALMITOYLOXY)-(2RS)-PROPYL]-L-CYSTEINE |
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| CAS号 | 87420-41-5 | 分子量 | 910.46300 | |
| 密度 | 0.966g/cm3 | 沸点 | 907.8ºC at 760 mmHg | |
| 分子式 | C54H103NO7S | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | 502.8ºC |
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Chronic pulmonary LPS tolerance induces selective immunosuppression while maintaining the neutrophilic response.
Shock 33(2) , 162-9, (2010) LPS challenge causes potent activation of innate immunity. Because LPS is ubiquitously present in ambient air, repeated inhalation may lead to activation of the pulmonary immune response. If this activation is unregulated, chronic LPS inhalation would lead to... |
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Attenuated pathogenesis of polymicrobial peritonitis in mice after TLR2 agonist pre-treatment involves ST2 up-regulation.
Int. Immunol. 17(8) , 1035-46, (2005) The innate immune system uses Toll-like receptors (TLRs) to activate and instruct immune responses against microbial pathogens. Administration of TLR agonists to mice induces a state of hyporesponsiveness, or tolerance, characterized by reduced cytokine produ... |
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Improved intranasal immunization with live-attenuated measles virus after co-inoculation of the lipopeptide MALP-2.
Vaccine 23(39) , 4721-6, (2005) The macrophage-activating lipopeptide with a molecular weight of 2kDa (MALP-2) activates antigen presenting cells of human, mouse and rat origin in vitro and in vivo. Here, we demonstrate that MALP-2 induces MIP1alpha and beta, MIP-2, Gro, TNFalpha, IL1alpha ... |
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NK cells from tuberculous pleurisy express high ICAM-1 levels and exert stimulatory effect on local T cells.
Eur. J. Immunol. 39(9) , 2450-8, (2009) Tuberculous pleurisy, one of the most common manifestations of extrapulmonary tuberculosis, is characterized by a T-cell-mediated hypersensitivity reaction along with a Th1 immune profile. In this study, we investigated functional cross-talk among T and NK ce... |
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A novel method for kinetic measurements of rare cell proliferation using Cellometer image-based cytometry.
J. Immunol. Methods 377(1-2) , 8-14, (2012) Cell proliferation is an important assay for pharmaceutical and biomedical research to test the effects of a variety of treatments on cultured primary cells or cell lines. For immunological studies, the ability to perform rapid cell proliferation analysis all... |
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IL-6-inducing whole yeast-based immunotherapy directly controls IL-12-dependent CD8 T-cell responses.
J. Immunother. 35(1) , 14-22, (2012) In current clinical trails, whole yeast-based immunotherapy expressing hepatitis C viral antigens demonstrated statistically significant improvement in end of treatment responses when combined with type I interferon based standard of care, even in standard of... |
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Ligation of TLR2 and TLR4 on murine bone marrow-derived mesenchymal stem cells triggers differential effects on their immunosuppressive activity.
Cell. Immunol. 271(1) , 147-56, (2011) Mesenchymal stem cells (MSCs) have potent regulatory effects on immune and inflammatory responses. Recently the findings of functional TLR expression on MSC implicates these receptors in the function established for MSCs. Here we specially investigated the ef... |
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Effect of Pam3Cys induced protection on the therapeutic efficacy of miltefosine against experimental visceral leishmaniasis.
Peptides 32(10) , 2131-3, (2011) Prophylactic potential of synthetic bacterial lipopeptide and a TLR2 agonist, Pam3Cys was first evaluated against experimental visceral leishmaniasis in rodent model. After establishing the potential its effect on therapeutic efficacy of miltefosine was also ... |
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Enhancement of toll-like receptor 2-mediated immune responses by AIMP1, a novel cytokine, in mouse dendritic cells.
Immunology 134(1) , 73-81, (2011) Aminoacyl tRNA synthetase-interacting protein 1 (AIMP1) is a novel pleiotropic cytokine that was identified initially from Meth A-induced fibrosarcoma. It is expressed in the salivary glands, small intestine and large intestine, and is associated with the inn... |
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A novel anti-mycobacterial function of mitogen-activated protein kinase phosphatase-1.
BMC Immunol. 10 , 64, (2009) Mycobacterium tuberculosis (MTB) is a major cause of morbidity and mortality in the world. To combat against this pathogen, immune cells release cytokines including tumor necrosis factor-alpha (TNF-alpha), which is pivotal in the development of protective gra... |