艾替班特乙酸盐
艾替班特乙酸盐结构式
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常用名 | 艾替班特乙酸盐 | 英文名 | Icatibant acetate |
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| CAS号 | 138614-30-9 | 分子量 | 1364.57000 | |
| 密度 | 1.6g/cm3 | 沸点 | N/A | |
| 分子式 | C61H93N19O15S | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | N/A |
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Contribution of endogenous bradykinin to fibrinolysis, inflammation, and blood product transfusion following cardiac surgery: a randomized clinical trial.
Clin. Pharmacol. Ther. 93(4) , 326-34, (2013) Bradykinin increases during cardiopulmonary bypass (CPB) and stimulates the release of nitric oxide, inflammatory cytokines, and tissue-type plasminogen activator (t-PA), acting through its B2 receptor. This study tested the hypothesis that endogenous bradyki... |
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Interaction between bradykinin and natriuretic peptides via RGS protein activation in HEK-293 cells.
Am. J. Physiol. Cell Physiol. 303(12) , C1260-8, (2012) In this study, the interaction of natriuretic peptides (NP) and bradykinin (BK) signaling pathways was identified by measuring membrane potential (V(m)) and intracellular Ca(2+) using the patch-clamp technique and flow cytometry in HEK-293 cells. BK and NP re... |
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Influence of kinin peptides on monocyte-endothelial cell adhesion.
J. Cell. Biochem. 115(11) , 1985-95, (2014) Adhesion of leukocytes to vascular endothelium in response to proinflammatory mediators is an important component of the overall inflammatory reaction. In the current work, we used a retinoic acid-differentiated human promonocytic cell line, U937 and a human ... |
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A plant Kunitz-type inhibitor mimics bradykinin-induced cytosolic calcium increase and intestinal smooth muscle contraction.
Biol. Chem. 393(9) , 943-57, (2012) BbKI is a kallikrein inhibitor with a reactive site sequence similar to that of kinins, the vasoactive peptides inserted in kininogen moieties. This structural similarity probably contributes to the strong interaction with plasma kallikrein, the enzyme that r... |
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Update on treatment of hereditary angioedema.
Asian Pac. J. Allergy Immunol. 30(2) , 89-98, (2012) Hereditary Angioedema (HAE) is a rare disease characterized by recurrent, self-limiting episodes of swelling. New therapies have recently emerged and are now available; however, many physicians are not aware of the new medications, and their indications and c... |
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Nonhistaminergic idiopathic angioedema: clinical response to icatibant.
J. Investig. Allergol. Clin. Immunol. 22(7) , 520-1, (2012)
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Icatibant , the bradykinin B2 receptor antagonist with target to the interconnected kinin systems.
Expert Opin. Pharmacother. 13(15) , 2233-47, (2012) HOE-140/ Icatibant is a selective, competitive antagonist to bradykinin (BK) against its binding to the kinin B2 receptor. Substitution of five non-proteogeneic amino acid analogues makes icatibant resistant to degradation by metalloproteases of kinin catabol... |
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The kallikrein–kinin-system in head and neck squamous cell carcinoma (HNSCC) and its role in tumour survival, invasion, migration and response to radiotherapy
Oral Oncol. 48(12) , 1208-19, (2012) Background In this study, we investigated the role of the kallikrein–kinin-system in head and neck squamous cell carcinoma (HNSCC) and its implication on tumour survival, invasion, migration and response to radiotherapy. |
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Antihypertensive and renoprotective effect of the kinin pathway activated by potassium in a model of salt sensitivity following overload proteinuria.
Am. J. Physiol. Renal Physiol. 304(12) , F1399-410, (2013) The albumin overload model induces proteinuria and tubulointersitial damage, followed by hypertension when rats are exposed to a hypersodic diet. To understand the effect of kinin system stimulation on salt-sensitive hypertension and to explore its potential ... |
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Hereditary angioedema treatment options: the availability of new therapies.
Ann. Med. 44(6) , 523-9, (2012) Hereditary angioedema (HAE) is a potentially life-threatening autosomal dominant disease characterized by recurrent episodes of oedema, commonly occurring in the skin, abdomen, and upper respiratory tract. After many years during which limited treatment optio... |