SDZ 205-557盐酸盐
SDZ 205-557盐酸盐结构式
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常用名 | SDZ 205-557盐酸盐 | 英文名 | SDZ-205 557 HCL |
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| CAS号 | 137196-67-9 | 分子量 | 337.24200 | |
| 密度 | 1.177g/cm3 | 沸点 | 436.8ºC at 760mmHg | |
| 分子式 | C14H22Cl2N2O3 | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | 217.9ºC |
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Central cholinergic antinociception induced by 5HT4 agonists: BIMU 1 and BIMU 8.
Life Sci. 58(25) , 2297-309, (1996) The antinociceptive effect of two 5-HT4 agonists, BIMU 1 and BIMU 8, were examined in mice and rats by using the hot-plate, abdominal constriction and paw-pressure tests. In both species, BIMU 1 (10-20 mg kg-1 s.c. and 40-60 mg kg-1 p.o. in mice; 20 mg kg-1 i... |
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Serotonin receptor agonists that increase cyclic AMP positively regulate IGF-I in mouse mandibular mesenchymal cells.
Dev. Neurosci. 21(2) , 105-12, (1999) Evidence from the present study suggests that activation of both 5-HT(1A) and 5-HT(4) (5-hydroxytryptamine) receptor subtypes stimulates cyclic adenosine monophosphate (cAMP) synthesis in cultured embryonic mouse mandibular mesenchymal cells (micromass cultur... |
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5-HT4 receptors in isolated human corpus cavernosum?
Int. J. Impot. Res. 11(4) , 219-25, (1999) The novel serotonin subtype-4 (5-HT4) receptor agonist, SC53116 (SC), produced a limited relaxation of noradrenaline (NA) pre-contracted human corpus cavernosum (CC) smooth muscle in vitro. This effect was not significantly attenuated by the 5-HT4 antagonist ... |
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Increased defaecation caused by 5-HT4 receptor activation in the mouse.
Eur. J. Pharmacol. 308(2) , 181-6, (1996) The precursor to 5-hydroxytryptamine (5-HT), 5-hydroxytryptophan, (5-HTP, 5-50 mg.kg-1) administered subcutaneously (s.c.) to conscious, fed mice caused a dose dependent increase in faecal pellet and fluid output. To avoid provoking watery diarrhoea, all expe... |
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Characterization of 5-hydroxytryptamine (5-HT) receptor subtypes influencing colonic motility in conscious dogs.
Naunyn Schmiedebergs Arch. Pharmacol. 353(5) , 489-98, (1996) We examined the effects of exogenous 5-hydroxytryptamine (5-HT) and selective 5-HT receptor agonists and antagonists on proximal, middle and distal colonic motility in conscious fasted dogs with extraluminal force transducers implanted chronically. 5-HT (0.00... |
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Antagonism by SB 204070 of 5-HT-evoked contractions in the dog stomach: an in-vivo model of 5-HT4 receptor function.
J. Pharm. Pharmacol. 47(3) , 219-22, (1995) Skh:HR-1 hairless mice were irradiated chronically with sub-erythemal doses of UVB radiation, and a number of biochemical parameters in the skin were determined after 6, 12, 18, and 24 wk of exposure. The parameters measured were water, collagen, elastin, and... |
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Characterization of the contractile response induced by 5-methoxytryptamine in rat stomach fundus strips.
Eur. J. Pharmacol. 318(2-3) , 403-9, (1996) This study examined effects of 5-methoxytryptamine (5-MOT), an agonist at 5-HT4 and 5-HT2B receptors, on the contractile response and acetylcholine release in rat stomach fundus strips. 5-MOT (10(-9)-10(-5) M) produced a concentration-dependent increase in th... |
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Antagonism of peripheral 5-HT4 receptors reduces visceral and cutaneous pain in mice, and induces visceral analgesia after simultaneous inactivation of 5-HT3 receptors.
Brain Res. 788(1-2) , 20-4, (1998) The role of 5-HT4 receptors on cutaneous and visceral pain remains largely unexplored. The objective of this study was to establish the activity profile of SDZ 205-557, a 5-HT4 antagonist, on cutaneous (hotplate) and visceral (writhing) models of pain, after ... |
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5-HT is present in nerves of guinea pig sphincter of Oddi and depolarizes sphincter of Oddi neurons.
Am. J. Physiol. 275(5 Pt 1) , G1018-27, (1998) This study involved immunohistochemistry and intracellular electrophysiology to investigate serotonergic neurotransmission in the sphincter of Oddi (SO). 5-Hydroxytryptamine (HT)-positive neurons (14 cells/preparation) and nerve fibers were observed in the ga... |
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p-Chloroamphetamine, a serotonin-releasing drug, elicited in rats a hyperglycemia mediated by the 5-HT1A and 5-HT2B/2C receptors.
Eur. J. Pharmacol. 359(2-3) , 185-90, (1998) The effects of a serotonin (5-HT) releasing drug, p-chloroamphetamine, on plasma glucose levels were investigated in rats. p-Chloroamphetamine elicited a significant hyperglycemia. The hyperglycemic effects of p-chloroamphetamine were completely prevented by ... |