盐酸尼索西汀
盐酸尼索西汀结构式
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常用名 | 盐酸尼索西汀 | 英文名 | Nisoxetine hydrochloride |
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| CAS号 | 57754-86-6 | 分子量 | 307.81500 | |
| 密度 | 1.054g/cm3 | 沸点 | 404.8ºC at 760mmHg | |
| 分子式 | C17H22ClNO2 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 170.6ºC |
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Serotonergic signalling suppresses ataxin 3 aggregation and neurotoxicity in animal models of Machado-Joseph disease.
Brain 138 , 3221-37, (2015) Polyglutamine diseases are a class of dominantly inherited neurodegenerative disorders for which there is no effective treatment. Here we provide evidence that activation of serotonergic signalling is beneficial in animal models of Machado-Joseph disease. We ... |
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The pro-inflammatory cytokine TNF-α regulates the activity and expression of the serotonin transporter (SERT) in astrocytes.
Neurochem. Res. 38(4) , 694-704, (2013) Pro-inflammatory cytokines have been implicated in the precipitation of depression and related disorders, and the antidepressant sensitive serotonin transporter (SERT) may be a major target for immune regulation in these disorders. Here, we focus on astrocyte... |
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Plasma membrane monoamine transporters: structure, regulation and function.
Nat. Rev. Neurosci. 4 , 13-25, (2003)
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N-Ethylmaleimide differentially inhibits substrate uptake by and ligand binding to the noradrenaline transporter.
Naunyn Schmiedebergs Arch. Pharmacol. 377(3) , 255-65, (2008) Using transfected HEK293 cells that express the human (h) noradrenaline transporter (hNAT), we show differential inhibitory effects of the thiol reagent N-ethylmaleimide (NEM) on [(3)H]NA uptake and [(3)H]nisoxetine binding. Irreversible inhibition of uptake ... |
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Endothelin-1 and -3 modulate the neuronal norepinephrine transporter through multiple signalling pathways in the rat posterior hypothalamus.
Neurochem. Int. 57(3) , 306-13, (2010) We have previously reported that endothelin-1 and -3 modulate different steps of noradrenergic transmission in the hypothalamus. We showed that endothelins modify neuronal norepinephrine transport activity through the regulation of the kinetic constant and in... |
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α2-Adrenergic agonists including xylazine and dexmedetomidine inhibit norepinephrine transporter function in SK-N-SH cells.
Neurosci. Lett. 541 , 184-9, (2013) α2-Adrenergic agonists simulate norepinephrine (NE) action on α2 receptors of sympathetic neurons to mediate feedback inhibition of NE release. These agents are used as valuable adjuncts for management of hypertension and for anesthesia. Their action, equival... |
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Insensitivity of NMRI mice to selective serotonin reuptake inhibitors in the tail suspension test can be reversed by co-treatment with 5-hydroxytryptophan.
Psychopharmacology 199(2) , 137-50, (2008) Exploring differences between mouse strains in drug effects in models of antidepressant-like activity may provide clues to the neurobiology of antidepressant responses.The objective of this study was to explore whether insensitivity to selective serotonin reu... |
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Site-directed mutations near transmembrane domain 1 alter conformation and function of norepinephrine and dopamine transporters.
Mol. Pharmacol. 79(3) , 520-32, (2011) The human dopamine and norepinephrine transporters (hDAT and hNET, respectively) control neurotransmitter levels within the synaptic cleft and are the site of action for amphetamine (AMPH) and cocaine. We investigated the role of a threonine residue within th... |
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Differential response of the central noradrenergic nervous system to the loss of locus coeruleus neurons in Parkinson's disease and Alzheimer's disease.
Brain Res. 1373 , 240-52, (2011) In Parkinson's disease (PD), there is a significant loss of noradrenergic neurons in the locus coeruleus (LC) in addition to the loss of dopaminergic neurons in the substantia nigra (SN). The goal of this study was to determine if the surviving LC noradrenerg... |
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Nisoxetine produces local but not systemic analgesia against cutaneous nociceptive stimuli in the rat.
Eur. J. Pharmacol. 675(1-3) , 22-5, (2012) The aim of this study was to evaluate the local anesthetic effect of nisoxetine as infiltrative cutaneous analgesic. After rats were injected subcutaneously with nisoxetine, dose-response curves were constructed. The cutaneous anesthetic effect of nisoxetine ... |