钾离子荧光探针
钾离子荧光探针结构式
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常用名 | 钾离子荧光探针 | 英文名 | PBFI-AM |
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| CAS号 | 124549-23-1 | 分子量 | 1171.11 | |
| 密度 | 1.295g/cm3 | 沸点 | 1136.6ºC at 760 mmHg | |
| 分子式 | C58H62N2O24 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 641.2ºC |
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Granzyme B-induced neurotoxicity is mediated via activation of PAR-1 receptor and Kv1.3 channel.
PLoS ONE 7(8) , e43950, (2012) Increasing evidence supports a critical role of T cells in neurodegeneration associated with acute and subacute brain inflammatory disorders. Granzyme B (GrB), released by activated T cells, is a cytotoxic proteinase which may induce perforin-independent neur... |
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Fluorescent indicators for cytosolic sodium.
J. Biol. Chem. 264 , 19449, (1989) Fluorescent indicators sensitive to cytosolic concentrations of free Na+ have been synthesized and characterized. They consist of a crown ether, 1,7-diaza-4,10,13-trioxacyclopentadecane, linked via its nitrogens to fluorophores bearing additional liganding ce... |
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P. Jezek et al.
J. Biol. Chem. 264 , 10522, (1990)
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Mitochondrial K+ as modulator of Ca(2+)-dependent cytotoxicity in hepatocytes. Novel application of the K(+)-sensitive dye PBFI (K(+)-binding benzofuran isophthalate) to assess free mitochondrial K+ concentrations.
Biochem. J. 299 , 539, (1994) In isolated rat hepatocytes a sustained high increase in intracellular free Ca2+ ([Ca2+]i), induced by extracellular ATP, is associated with mitochondrial dysfunction and cell death. The Ca(2+)-induced effects are Pi-dependent and less severe when the intrace... |
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4-aminopyridine decreases progesterone production by porcine granulosa cells.
Reprod. Biol. Endocrinol. 1 , 31, (2004) Ion channels occur as large families of related genes with cell-specific expression patterns. Granulosa cells have been shown to express voltage-gated potassium channels from more than one family. The purpose of this study was to determine the effects of 4-am... |
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Acid-sensing ion channel 1a contributes to the effect of extracellular acidosis on NLRP1 inflammasome activation in cortical neurons.
J. Neuroinflammation 12 , 246, (2015) Acid-sensing ion channels (ASICs) are cation channels which were activated by extracellular acidosis and involved in various physiological and pathological processes in the nervous system. Inflammasome is a key component of the innate immune response in host ... |