硝基乙酸乙酯
硝基乙酸乙酯结构式
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常用名 | 硝基乙酸乙酯 | 英文名 | ETHYL NITROACETATE |
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| CAS号 | 626-35-7 | 分子量 | 133.10 | |
| 密度 | 1.2±0.1 g/cm3 | 沸点 | 208.6±0.0 °C at 760 mmHg | |
| 分子式 | C4H7NO4 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 92.2±0.0 °C |
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[Experimental establishment of the maximum permissible concentration of the methyl and ethyl esters of nitroacetic acid].
Gig. Tr. Prof. Zabol. (7) , 49-51, (1980)
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Synthesis and biological evaluation of DL-4,4-difluoroglutamic acid and DL-gamma,gamma-difluoromethotrexate.
J. Med. Chem. 39(1) , 66-72, (1996) DL-4,4-Difluoroglutamic acid (DL-4,4-F2Glu) and its methotrexate analogue, DL-gamma,gamma-difluoromethotrexate (DL-gamma,gamma-F2MTX), were synthesized and evaluated as alternate substrates or inhibitors of folate-dependent enzymes. Synthesis of DL-4,4-F2Glu ... |
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Formation of γ-oxoacids and 1H-pyrrol-2(5H)-ones from α,β-unsaturated ketones and ethyl nitroacetate.
J. Org. Chem. 75(21) , 7435-8, (2010) Michael addition of ethyl nitroacetate on α,β-unsaturated ketones followed by Nef oxidation under hydrolytic conditions yields γ-oxoacids instead of the corresponding α,δ-dioxoesters. A concerted decarboxylation step is proposed on the basis of computational ... |
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Facile synthesis of alpha,alpha-diisobutylglycine and anchoring its derivatives onto PAL-PEG-PS resin.
J. Org. Chem. 68(25) , 9854-7, (2003) alpha,alpha-Diisobutylglycine has been synthesized using a Pd-mediated dialkylation of ethyl nitroacetate as a key first step. The free alphaalphaAA is N(alpha)-protected and has been applied to the assembly of conformationally constrained peptide analogues. ... |
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Functionalization of pyrimidine and purine nucleosides at C4 and C6: C-nucleophilic substitution of their C4- and C6-(1,2,4-triazol-1-yl) derivatives.
Nucleosides Nucleotides Nucleic Acids 24(5-7) , 1043-6, (2005) A study of C-nucleophilic substitution at the C4-position on pyrimidine and C6-position on 2'-deoxyguanosine to produce novel nucleosides is presented with the spectroscopic properties of their respective substitution products. C4-(1,2,4-triazol-1-yl) pyrimid... |
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Acid-base-catalysed condensation reaction in water: isoxazolines and isoxazoles from nitroacetates and dipolarophiles.
Chemistry 18(7) , 2081-93, (2012) Base-catalysed condensation reactions of nitroacetic esters with dipolarophiles to give isoxazole derivatives proceed faster, and often with higher yields, in the presence of water than in organic solvents such as chloroform. Kinetic profiles show that induct... |
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Michael additions versus cycloaddition condensations with ethyl nitroacetate and electron-deficient olefins.
Chemistry 15(32) , 7940-8, (2009) Ethyl nitroacetate (1) reacts with electron-poor olefins in the presence of a base to give either the Michael adducts 3 or the isoxazoline cycloadducts 4, resulting from water elimination. The proportions of the two products depend on the reaction conditions ... |