羟基乙酰胺
羟基乙酰胺结构式
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常用名 | 羟基乙酰胺 | 英文名 | glycolamide |
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| CAS号 | 598-42-5 | 分子量 | 75.067 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 338.5±25.0 °C at 760 mmHg | |
| 分子式 | C2H5NO2 | 熔点 | 118-120ºC(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 158.5±23.2 °C |
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Isolation of amidase-negative mutants of Pseudomonas aeruginosa using glycollamide as a selective agent.
J. Gen. Microbiol. 133(6) , 1527-33, (1987) A positive selection is described for isolating amidase-negative mutants from Pseudomonas aeruginosa strains. The method is based on the conversion, via amidase activity, of glycollamide to glycollate which is growth inhibitory. Three types of mutant were iso... |
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Extraction capacity of diglycolamide derivatives for Ca(II), Nd(III) and Zr(IV) from nitric acid to N-dodecane containing a solvent modifier.
Anal. Sci. 21(10) , 1171-5, (2005) In order to evaluate the extraction property of new extractants, diglycolamide (DGA) compounds, we investigated the maximum extraction of di-, tri-, and tetravalent metal ions using nitric acid and n-dodecane. The limits of metal concentration (LOC) for Ca(II... |
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Synthesis and evaluation ofin vitroanti-tuberculosis activity ofN-substituted glycolamides
Eur. J. Med. Chem. 44(1) , 289-95, (2009) On the basis of the structural similarity of N-substituted glycolamides with N-glycolyl muramic acid residues of the cell wall of Mycobacterium tuberculosis, a series of these compounds were designed and synthesized by the reaction of glycolic acid acetonide ... |
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Activity profile of glycolamide ester prodrugs of ibuprofen.
Drug Dev. Ind. Pharm. 27(1) , 63-70, (2001) Glycolamide esters of ibuprofen (I), namely, unsubstituted (II), N,N dimethyl (III), and N,N diethyl (IV), were synthesized and studied for different physicochemical, pharmacological, and toxicological properties. They were comparable with I in respect of ant... |
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A QSAR approach for the prediction of stability of benzoglycolamide ester prodrugs.
Chem. Pharm. Bull. 54(8) , 1067-71, (2006) A method consisting of quantitative structure-activity relationship (QSAR) (MLR) was developed to predict the hydrolytic rate constant of 37 benzoglycolamide ester prodrugs. The regression method was used as a calibration model for calculating the hydrolytic ... |
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Diglycolamide-functionalized calix[4]arenes showing unusual complexation of actinide ions in room temperature ionic liquids: role of ligand structure, radiolytic stability, emission spectroscopy, and thermodynamic studies.
Inorg. Chem. 52(5) , 2533-41, (2013) Diglycolamide-functionalized calix[4]arenes (C4DGAs) with varying structural modifications were evaluated for actinide complexation from their extraction behavior toward actinide ions such as UO2(2+), Pu(4+), PuO2(2+), and Am(3+) in the room temperature ionic... |
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Plutonium(IV) complexation by diglycolamide ligands--coordination chemistry insight into TODGA-based actinide separations.
Chem. Commun. (Camb.) 48(78) , 9732-4, (2012) Complexation of Pu(IV) with TMDGA, TEDGA, and TODGA diglycolamide ligands was followed by vis-NIR spectroscopy. A crystal structure determination reveals that TMDGA forms a 1 : 3 homoleptic Pu(IV) complex with the nitrate anions forced into the outer coordina... |
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Novel isosorbide-based substrates for human butyrylcholinesterase.
Chem. Biol. Interact. 157-158 , 317-9, (2005) Butyrylcholinesterase [EC 3.1.1.8] present widely in mammalian tissue does not have a precisely defined biological function or known endogenous substrate. However, it plays an important role in the detoxification of certain xenobiotics and is an established v... |
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Prodrug designing of NSAIDs.
Mini Rev. Med. Chem. 9(1) , 124-39, (2009) Non-steroidal anti-inflammatory drugs (NSAIDs), commonly used for the treatment of chronic inflammatory diseases suffer from several undesired side effects, the most important being gastrointestinal (GI) irritation and ulceration. The prodrug designing is one... |
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2-phenyl-4-piperazinylbenzimidazoles: orally active inhibitors of the gonadotropin releasing hormone (GnRH) receptor.
Bioorg. Med. Chem. 16(13) , 6617-40, (2008) Antagonism of the gonadotropin releasing hormone (GnRH) receptor has shown positive clinical results in numerous reproductive tissue disorders such as endometriosis, prostate cancer and others. Traditional therapy has been limited to peptide agonists and anta... |