α-甲基-D-甘露糖苷
α-甲基-D-甘露糖苷结构式
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常用名 | α-甲基-D-甘露糖苷 | 英文名 | Methyl α-D-mannopyranoside |
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| CAS号 | 617-04-9 | 分子量 | 194.182 | |
| 密度 | 1.5±0.1 g/cm3 | 沸点 | 389.1±42.0 °C at 760 mmHg | |
| 分子式 | C7H14O6 | 熔点 | 193-196ºC | |
| MSDS | 中文版 美版 | 闪点 | 189.1±27.9 °C |
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Synthesis of glycopeptide dendrimers, dimerization and affinity for Concanavalin A.
Bioorg. Med. Chem. 19 , 2879-87, (2011) We described herein the synthesis of second generation glycopeptide dendrimers G2a-g presenting variable amino acids placed internally into the multivalent scaffold. The effect of such structural modulation on recognition processes by Concanavalin A (Con A), ... |
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Redox-responsive and calcium-dependent switching of glycosyldisulfide interactions with Concanavalin A.
Bioorg. Med. Chem. Lett. 15 , 2707-10, (2005) Glycosyldisulfides can interact efficiently with carbohydrate-binding entities. This has been shown for a range of thiosaccharide dimers when tested for their effects against the lectin Concanavalin A using a modified quartz crystal microbalance-technique. Co... |
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BK Virus replication in vitro: limited effect of drugs interfering with viral uptake and intracellular transport.
Antimicrob. Agents Chemother. 51 , 4492-4, (2007) BK virus is an important pathogen in kidney transplant recipients. In vitro studies demonstrated slight antiviral activity for chloroquine and nystatin. A sialic acid derivative, BTB11968, was identified as a lead compound for further development. |
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Towards a stable noeuromycin analog with a D-manno configuration: synthesis and glycosidase inhibition of D-manno-like tri- and tetrahydroxylated azepanes.
Bioorg. Med. Chem. 20 , 641-9, (2012) Noeuromycin is a highly potent albeit unstable glycosidase inhibitor due to its hemiaminal function. While stable D-gluco-like analogs have been reported, no data are available for D-manno-like structures. A series of tri- and tetrahydroxylated seven-membered... |
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Prevention of colonization of the urinary tract of mice with Escherichia coli by blocking of bacterial adherence with methyl alpha-D-mannopyranoside.
J. Infect. Dis. 139 , 329-32, (1979) Methyl alpha-D-mannopyranoside (alpha MM), a competitor inhibitor of the binding of mannose by Escherichia coli, was tested for its ability to prevent infection of the urinary tract of mice with infective strains of the organisms. Injection of the bacteria in... |
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Mapping of the primary mannose binding site of pradimicin A.
J. Am. Chem. Soc. 133 , 17485-93, (2011) Pradimicin A (PRM-A) is an actinomycete-derived antibiotic with the lectin-like property of being able to recognize D-mannopyranoside (Man) in the presence of Ca(2+) ion. PRM-A and its derivatives have been attracting a great deal of attention as the only fam... |
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Design, synthesis and biological evaluation of mannosyl triazoles as FimH antagonists.
Bioorg. Med. Chem. 19 , 6454-73, (2011) Urinary tract infection (UTI) caused by uropathogenic Escherichia coli (UPEC) is one of the most prevalent infectious diseases. Particularly affected are women, who have a 40-50% risk to experience at least one symptomatic UTI episode at some time during thei... |
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The pancreatic zymogen granule membrane protein, GP2, binds Escherichia coli Type 1 fimbriae.
BMC Gastroenterol. 9 , 58, (2009) GP2 is the major membrane protein present in the pancreatic zymogen granule, and is cleaved and released into the pancreatic duct along with exocrine secretions. The function of GP2 is unknown. GP2's amino acid sequence is most similar to that of uromodulin, ... |
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Rational design of novel glycomimetics: inhibitors of concanavalin A.
Bioorg. Med. Chem. Lett. 18 , 6573-5, (2008) A virtual screening approach was used to identify new glycomimetics. The National Cancer Institute Diversity Set was docked into the carbohydrate binding site of the lectin concanavalin A (ConA). The resulting poses were analyzed and 19 molecules were tested ... |
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Prevention of nonspecific binding of avidin.
Meth. Enzymol. 184 , 201, (1990)
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