1-[N,O-二(5-异喹啉磺酰基)-N-甲基-L-型酪氨酸]-4-苯基哌嗪
![1-[N,O-二(5-异喹啉磺酰基)-N-甲基-L-型酪氨酸]-4-苯基哌嗪结构式](https://image.chemsrc.com/caspic/302/127191-97-3.png)
1-[N,O-二(5-异喹啉磺酰基)-N-甲基-L-型酪氨酸]-4-苯基哌嗪结构式
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常用名 | 1-[N,O-二(5-异喹啉磺酰基)-N-甲基-L-型酪氨酸]-4-苯基哌嗪 | 英文名 | KN-62 |
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| CAS号 | 127191-97-3 | 分子量 | 721.844 | |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | 964.7±75.0 °C at 760 mmHg | |
| 分子式 | C38H35N5O6S2 | 熔点 | 92-94°C | |
| MSDS | 美版 | 闪点 | 537.3±37.1 °C |
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The Ca²⁺-calmodulin-Ca²⁺/calmodulin-dependent protein kinase II signaling pathway is involved in oxidative stress-induced mitochondrial permeability transition and apoptosis in isolated rat hepatocytes.
Arch. Toxicol. 88(9) , 1695-709, (2014) Oxidative stress (OS) is a common event in most hepatopathies, leading to mitochondrial permeability transition pore (MPTP) formation and further exacerbation of both OS from mitochondrial origin and cell death. Intracellular Ca²⁺ increase plays a permissive ... |
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R270C polymorphism leads to loss of function of the canine P2X7 receptor.
Physiol. Genomics 46(14) , 512-22, (2014) The relative function of the P2X7 receptor, an ATP-gated ion channel, varies between humans due to polymorphisms in the P2RX7 gene. This study aimed to assess the functional impact of P2X7 variation in a random sample of the canine population. Blood and genom... |
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Modulation of P2X4/P2X7/Pannexin-1 sensitivity to extracellular ATP via Ivermectin induces a non-apoptotic and inflammatory form of cancer cell death.
Sci. Rep. 5 , 16222, (2015) Overexpression of P2X7 receptors correlates with tumor growth and metastasis. Yet, release of ATP is associated with immunogenic cancer cell death as well as inflammatory responses caused by necrotic cell death at sites of trauma or ischemia-reperfusion injur... |
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Cathelicidin peptide LL-37 increases UVB-triggered inflammasome activation: possible implications for rosacea.
J. Dermatol. Sci. 76(3) , 173-9, (2014) In patients with rosacea, environmental stressors, especially UVB radiation, trigger disease flares that are characterized by inflammation and vascular hyperactivity. An altered innate immune detection and response system, modulated to a large extent by the a... |
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Calcium Signaling Is Required for Erythroid Enucleation.
PLoS ONE 11 , e0146201, (2016) Although erythroid enucleation, the property of erythroblasts to expel their nucleus, has been known for 7ore than a century, surprisingly little is known regarding the molecular mechanisms governing this unique developmental process. Here we show that simila... |
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Evidence for glycinergic GluN1/GluN3 NMDA receptors in hippocampal metaplasticity.
Neurobiol. Learn. Mem. 125 , 265-73, (2015) Hebbian, or associative, forms of synaptic plasticity are considered the molecular basis of learning and memory. However, associative synaptic modifications, including long-term potentiation (LTP) and depression (LTD), can form positive feedback loops which m... |
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Toluene diisocyanate: Induction of the autotaxin-lysophosphatidic acid axis and its association with airways symptoms.
Toxicol. Appl. Pharmacol. 287 , 222-31, (2015) Diisocyanates are industrial chemicals which have a wide range of applications in developed and developing countries. They are notorious lung toxicants and respiratory sensitizers. However, the mechanisms behind their adverse effects are not adequately charac... |
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The P2X7 receptor regulates cell survival, migration and invasion of pancreatic ductal adenocarcinoma cells.
Mol. Cancer 14 , 203, (2015) Pancreatic ductal adenocarcinoma (PDAC) is presently one of the cancers with the worst survival rates and least effective treatments. Moreover, total deaths due to PDAC are predicted to increase in the next 15 years. Therefore, novel insights into basic mecha... |
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Long-term potentiation at excitatory synaptic inputs to the intercalated cell masses of the amygdala.
Int. J. Neuropsychopharmacol. 17(8) , 1233-42, (2014) The intercalated cell masses (ITCs) of the amygdala are clusters of GABAergic interneurons that surround the basolateral complex of the amygdala. ITCs have been increasingly implicated in the acquisition and extinction of conditioned fear responses, but the u... |
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Roles of calcium/calmodulin-dependent kinase II in long-term memory formation in crickets.
PLoS ONE 9(9) , e107442, (2014) Ca(2+)/calmodulin (CaM)-dependent protein kinase II (CaMKII) is a key molecule in many systems of learning and memory in vertebrates, but roles of CaMKII in invertebrates have not been characterized in detail. We have suggested that serial activation of NO/cG... |