4,4',4''-(4-丙基-1H-吡唑-1,3,5-三基)三苯酚
4,4',4''-(4-丙基-1H-吡唑-1,3,5-三基)三苯酚结构式
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常用名 | 4,4',4''-(4-丙基-1H-吡唑-1,3,5-三基)三苯酚 | 英文名 | PPT |
|---|---|---|---|---|
| CAS号 | 263717-53-9 | 分子量 | 386.44 | |
| 密度 | 1.2±0.1 g/cm3 | 沸点 | 630.0±55.0 °C at 760 mmHg | |
| 分子式 | C24H22N2O3 | 熔点 | 230 ºC (decomp) | |
| MSDS | 中文版 美版 | 闪点 | 334.8±31.5 °C |
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Development of phenotypic and transcriptional biomarkers to evaluate relative activity of potentially estrogenic chemicals in ovariectomized mice.
Environ. Health Perspect. 123(4) , 344-52, (2015) Concerns regarding potential endocrine-disrupting chemicals (EDCs) have led to a need for methods to evaluate candidate estrogenic chemicals. Our previous evaluations of two such EDCs revealed a response similar to that of estradiol (E2) at 2 hr, but a less r... |
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Chemotherapeutic effect of tamoxifen on temozolomide-resistant gliomas.
Anticancer Drugs 26(3) , 293-300, (2015) Tamoxifen, a selective estrogen receptor modulator, is widely used in the chemotherapy of estrogen receptor-positive breast cancer. Recent studies have indicated that tamoxifen might have a potential chemotherapeutic effect on glioma. In the present study, we... |
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Estradiol and Estrogen Receptor Agonists Oppose Oncogenic Actions of Leptin in HepG2 Cells.
PLoS ONE 11 , e0151455, (2016) Obesity is a significant risk factor for certain cancers, including hepatocellular carcinoma (HCC). Leptin, a hormone secreted by white adipose tissue, precipitates HCC development. Epidemiology data show that men have a much higher incidence of HCC than wome... |
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Development of a recombinant human ovarian (BG1) cell line containing estrogen receptor α and β for improved detection of estrogenic/antiestrogenic chemicals.
Environ. Toxicol. Chem. 35 , 91-100, (2016) Estrogenic endocrine-disrupting chemicals are found in environmental and biological samples, commercial and consumer products, food, and numerous other sources. Given their ubiquitous nature and potential for adverse effects, a critical need exists for rapidl... |
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Neuroglobin overexpression induced by the 17β-Estradiol-Estrogen receptor-α Pathway reduces the sensitivity of MCF-7 Breast cancer cell to paclitaxel.
IUBMB Life 68 , 645-51, (2016) Although paclitaxel (Taxol) is an active chemotherapeutic agent for the treatment of breast cancer, not all breast tumors are sensitive to this drug. In particular, there is a wide agreement on the low sensitivity of estrogen receptor (ER) α-positive breast c... |
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Beneficial effects of estrogen in a mouse model of cerebrovascular insufficiency.
PLoS ONE 4(4) , e5159, (2009) The M(5) muscarinic acetylcholine receptor is known to play a crucial role in mediating acetylcholine dependent dilation of cerebral blood vessels. Previously, we reported that male M(5) muscarinic acetylcholine knockout mice (M5R(-/-) mice) suffer from a con... |
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Estrogens stimulate serotonin neurons to inhibit binge-like eating in mice.
J. Clin. Invest. 124(10) , 4351-62, (2014) Binge eating afflicts approximately 5% of US adults, though effective treatments are limited. Here, we showed that estrogen replacement substantially suppresses binge-like eating behavior in ovariectomized female mice. Estrogen-dependent inhibition of binge-l... |