氯屈膦酸二钠
氯屈膦酸二钠结构式
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常用名 | 氯屈膦酸二钠 | 英文名 | Clodronate Disodium |
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| CAS号 | 22560-50-5 | 分子量 | 288.856 | |
| 密度 | 2.306g/cm3 | 沸点 | 474.7ºC at 760mmHg | |
| 分子式 | CH2Cl2Na2O6P2 | 熔点 | >330ºC | |
| MSDS | 美版 | 闪点 | 240.9ºC |
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Analysis of iminosugars and other low molecular weight carbohydrates in Aglaonema sp. extracts by hydrophilic interaction liquid chromatography coupled to mass spectrometry.
J. Chromatogr. A. 1423 , 104-10, (2015) A method by hydrophilic interaction liquid chromatography coupled to tandem mass spectrometry (HILIC-MS(2)) has been successfully developed for the simultaneous analysis of bioactive iminosugars and other low molecular weight carbohydrates in Aglaonema leaf e... |
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Phosphatase inhibitors with anti-angiogenic effect in vitro.
APMIS 118(1) , 49-59, (2010) Levamisole has previously been identified as an inhibitor of angiogenesis in vitro and in vivo, but the mechanism behind the anti-angiogenic behavior has not yet been established. However, one known effect of levamisole is the inhibition of alkaline phosphata... |
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CD11b⁺, Ly6G⁺ cells produce type I interferon and exhibit tissue protective properties following peripheral virus infection.
PLoS Pathog. 7(11) , e1002374, (2011) The goal of the innate immune system is containment of a pathogen at the site of infection prior to the initiation of an effective adaptive immune response. However, effector mechanisms must be kept in check to combat the pathogen while simultaneously limitin... |
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¹¹¹In-anti-F4/80-A3-1 antibody: a novel tracer to image macrophages.
Eur. J. Nucl. Med. Mol. Imaging 42 , 1430-8, (2015) Here, the expression of F4/80 on the cell surface of murine macrophages was exploited to develop a novel imaging tracer that could visualize macrophages in vivo.The immunoreactive fraction and IC50 of anti-F4/80-A3-1, conjugated with diethylenetriaminepentaac... |
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Alveolar macrophages are critical for the inhibition of allergic asthma by mesenchymal stromal cells.
J. Immunol. 191(12) , 5914-24, (2013) Multipotent mesenchymal stromal cells (MSCs) possess reparative and immunoregulatory properties, making them attractive candidates for cellular therapy. However, the majority of MSCs administered i.v. encounter a pulmonary impasse and soon disappear from the ... |
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Liquid chromatography-mass spectrometry analysis of five bisphosphonates in equine urine and plasma.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 998-999 , 1-7, (2015) Bisphosphonates are used in the management of skeletal disorder in humans and horses, with tiludronic acid being the first licensed veterinary medicine in the treatment of lameness associated with degenerative joint disease. Bisphosphonates are prohibited in ... |
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Immunotherapy for hepatoma using a dual-function vector with both immunostimulatory and pim-3-silencing effects.
Mol. Cancer Ther. 13(6) , 1503-13, (2014) Tumorigenesis is an immortalization process in which the growth of normal cells is uncontrolled and programmed cell death is suppressed. Molecular biologic and immunologic studies have revealed that the aberrant expression of some proto-oncogenes boosts proli... |
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Macrophages are the determinant of resistance to and outcome of nonlethal Babesia microti infection in mice.
Infect. Immun. 83(1) , 8-16, (2015) In the present study, we examined the contributions of macrophages to the outcome of infection with Babesia microti, the etiological agent of human and rodent babesiosis, in BALB/c mice. Mice were treated with clodronate liposome at different times during the... |
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Complement C1q-induced activation of β-catenin signalling causes hypertensive arterial remodelling.
Nat. Commun. 6 , 6241, (2015) Hypertension induces structural remodelling of arteries, which leads to arteriosclerosis and end-organ damage. Hyperplasia of vascular smooth muscle cells (VSMCs) and infiltration of immune cells are the hallmark of hypertensive arterial remodelling. However,... |
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Prolonged antigen presentation following an acute virus infection requires direct and then cross-presentation.
J. Immunol. 193(8) , 4169-77, (2014) Antiviral CD8(+) T cell recognition of MHC class I-peptide complexes on the surface of professional APCs is a requisite step in an effective immune response following many potentially lethal infections. Although MHC class I-peptide production is thought to be... |