四聚赖氨酸
四聚赖氨酸结构式
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常用名 | 四聚赖氨酸 | 英文名 | H-Lys-Lys-Lys-Lys-OH AcOH |
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| CAS号 | 997-20-6 | 分子量 | 530.70400 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C24H50N8O5 | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | N/A |
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Serine 133 phosphorylation is not required for hippocampal CREB-mediated transcription and behavior.
Learn. Mem. 22(2) , 109-15, (2015) The cAMP response element (CRE)-binding protein, CREB, is a transcription factor whose activity in the brain is critical for long-term memory formation. Phosphorylation of Ser133 in the kinase-inducible domain (KID), that in turn leads to the recruitment of t... |
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Profiling of the Chromatin-associated Proteome Identifies HP1BP3 as a Novel Regulator of Cell Cycle Progression.
Mol. Cell. Proteomics 0 , (2014) The chromatin-associated proteome (chromatome) regulates cellular gene expression by restricting access of transcriptional machinery to template DNA, and dynamic re-modeling of chromatin structure is required to regulate critical cell functions including grow... |
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Cryptomphalus aspersa mollusc eggs extract promotes migration and prevents cutaneous ageing in keratinocytes and dermal fibroblasts in vitro.
Int. J. Cosmet. Sci. 37(1) , 41-55, (2015) The search of substances that minimize cutaneous ageing has increased in the last few years. Previous studies have described the regenerative properties of the secretion of the mollusc Cryptomphalus aspersa (C. aspersa) when applied topically.We evaluate the ... |
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Suppression of Th2 and Tfh immune reactions by Nr4a receptors in mature T reg cells.
J. Exp. Med. 212 , 1623-40, (2015) Regulatory T (T reg) cells are central mediators of immune suppression. As such, T reg cells are characterized by a distinct pattern of gene expression, which includes up-regulation of immunosuppressive genes and silencing of inflammatory cytokine genes. Alth... |
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A plastic SQSTM1/p62-dependent autophagic reserve maintains proteostasis and determines proteasome inhibitor susceptibility in multiple myeloma cells.
Autophagy 11 , 1161-78, (2015) Multiple myeloma (MM) is the paradigmatic proteasome inhibitor (PI) responsive cancer, but many patients fail to respond. An attractive target to enhance sensitivity is (macro)autophagy, recently found essential to bone marrow plasma cells, the normal counter... |
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Epigenetic alterations of the keratin 13 gene in oral squamous cell carcinoma.
BMC Cancer 14 , 988, (2015) Epigenetic modifications play important roles in the regulation of gene expression determining cellular phenotype as well as various pathologies such as cancer. Although the loss of keratin 13 (KRT13) is reportedly linked to malignant transformation of oral e... |
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Early life stress in fathers improves behavioural flexibility in their offspring.
Nat. Commun. 5 , 5466, (2014) Traumatic experiences in childhood can alter behavioural responses and increase the risk for psychopathologies across life, not only in the exposed individuals but also in their progeny. In some conditions, such experiences can however be beneficial and facil... |
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Epigenetic bivalent marking is permissive to the synergy of HDAC and PARP inhibitors on TXNIP expression in breast cancer cells.
Oncol. Rep. 33(5) , 2199-206, (2015) Studies on stem cell differentiation led to the identification of paused genes, characterized by the contemporary presence of both activator and repressor epigenetic markers (bivalent marking). TXNIP is an oncosuppressor gene the expression of which was reduc... |
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Endogenous interleukin (IL)-17A promotes pristane-induced systemic autoimmunity and lupus nephritis induced by pristane.
Clin. Exp. Immunol. 176(3) , 341-50, (2014) Interleukin (IL)-17A is increased both in serum and in kidney biopsies from patients with lupus nephritis, but direct evidence of pathogenicity is less well established. Administration of pristane to genetically intact mice results in the production of autoan... |
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Pharmacological Induction of Human Fetal Globin Gene in Hydroxyurea-Resistant Primary Adult Erythroid Cells.
Mol. Cell. Biol. 35 , 2541-53, (2015) Pharmacological induction of the fetal γ globin gene and the consequent formation of HbF (α2/γ2) in adult erythroid cells are one feasible therapeutic strategy for sickle cell disease (SCD) and severe β-thalassemias. Hydroxyurea (HU) is the current drug of ch... |