吡啶-3-硼酸
吡啶-3-硼酸结构式
|
常用名 | 吡啶-3-硼酸 | 英文名 | 3-Pyridylboronic acid |
|---|---|---|---|---|
| CAS号 | 1692-25-7 | 分子量 | 122.92 | |
| 密度 | 1.2±0.1 g/cm3 | 沸点 | 308.8±34.0 °C at 760 mmHg | |
| 分子式 | C5H6BNO2 | 熔点 | >300 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 140.5±25.7 °C |
|
A new access to 3-substituted-1(2H)-isoquinolone by tandem palladium-catalyzed intramolecular aminocarbonylation annulation.
Org. Biomol. Chem. 13th ed., 10 , 2683-2691, (2012) An original tribromide derivative based, palladium-catalyzed synthesis of 3-substituted-1(2H)-isoquinolone is described based on a regioselective Suzuki-Miyaura C-C coupling on o-halo-(2,2-dihalovinyl)-benzene followed by a palladium catalyzed amination-carbo... |
|
|
Synthesis and biological evaluation of novel amprenavir-based P1-substituted bi-aryl derivatives as ultra-potent HIV-1 protease inhibitors.
Bioorg. Med. Chem. Lett. 5th ed., 22 , 1976-1979, (2012) A series of P1-substituted biaryl amprenavir derivatives was designed and synthesized. These compounds were evaluated for enzyme inhibition and antiviral activity in vitro. Several compounds showed highly efficient antiviral activity with EC(50) values down t... |
|
|
Copper-mediated sequential cyanation of aryl C-B and arene C-H bonds using ammonium iodide and DMF.
J. Am. Chem. Soc. 5th ed., 134 , 2528-2531, (2012) The cyanation of aromatic boronic acids, boronate esters, and borate salts was developed under copper-mediated oxidative conditions using ammonium iodide and DMF as the source of nitrogen and carbon atom of the cyano unit, respectively. The procedure was succ... |
|
|
Phosphine-free Suzuki-Miyaura cross-coupling in aqueous media enables access to 2-C-aryl-glycosides.
Org. Lett. 7th ed., 14 , 1728-1731, (2012) A general strategy for the synthesis of 2-aryl-glycals and their elaboration to 2-C-aryl-α-glycosides and 1,5-anhydro-2-C-aryl-2-deoxy alditols are described. The use of reliable, efficient phosphine-free Suzuki-Miyaura cross-coupling of 2-iodoglycals in aque... |
|
|
Design and characterization of optimized adenosine A₂A/A₁ receptor antagonists for the treatment of Parkinson's disease.
J. Med. Chem. 3rd ed., 55 , 1402-1417, (2012) The design and characterization of two, dual adenosine A(2A)/A(1) receptor antagonists in several animal models of Parkinson's disease is described. Compound 1 was previously reported as a potential treatment for Parkinson's disease. Further characterization ... |
|
|
Pyridone methylsulfone hydroxamate LpxC inhibitors for the treatment of serious gram-negative infections.
J. Med. Chem. 4th ed., 55 , 1662-1670, (2012) The synthesis and biological activity of a new series of LpxC inhibitors represented by pyridone methylsulfone hydroxamate 2a is presented. Members of this series have improved solubility and free fraction when compared to compounds in the previously describe... |
|
|
Structural characterizations of oligopyridyl foldamers, α-helix mimetics.
J. Chem. Inf. Model. 2nd ed., 52 , 429-439, (2012) Protein-protein interactions are central to many biological processes, from intracellular communication to cytoskeleton assembly, and therefore represent an important class of targets for new therapeutics. The most common secondary structure in natural protei... |
|
|
Tetrahedron Lett. 47 , 6457, (2006)
|
|
|
Cu(acac)2-catalyzed N-arylations of phenylurea with arylboronic acid Gavade, S.; et al.
Synth. Commun. 11th ed., 42 , 1704-1714, (2012)
|
|
|
Synthesis of new linear poly(phenylpyridyl) chains Perato, S.; et al.
Tetrahedron 7th ed., 68 , 1910-1917, (2012)
|