norketobemidone
norketobemidone结构式
|
常用名 | norketobemidone | 英文名 | norketobemidone |
|---|---|---|---|---|
| CAS号 | 15847-72-0 | 分子量 | 233.30600 | |
| 密度 | 1.104g/cm3 | 沸点 | 402.2ºC at 760mmHg | |
| 分子式 | C14H19NO2 | 熔点 | N/A | |
| MSDS | N/A | 闪点 | 197ºC |
|
The mu1 and mu2 opioid receptor binding of ketobemidone, norketobemidone and 3-dimethylamino-1,1-diphenylbutene.
Pharmacol. Toxicol. 79(2) , 103-4, (1996)
|
|
|
Simultaneous determination of ketobemidone and its N-demethylated metabolite in patient plasma samples by gas chromatography mass spectrometry with selected ion monitoring.
Biomed. Mass Spectrom. 10(4) , 283-6, (1983) An analytical procedure has been developed for the simultaneous determination of ketobemidone and its N-demethylated metabolite, norketobemidone. After isolation from plasma and re-extraction to acidic aqueous phase, the two aminophenols were extracted as ion... |
|
|
Simultaneous analysis of five antidepressant drugs using direct injection of biofluids in a capillary restricted-access media-liquid chromatography-tandem mass spectrometry system.
J. Chromatogr. A. 1189(1-2) , 514-22, (2008) Direct analysis, with minimal sample pretreatment, of antidepressant drugs, fluoxetine, imipramine, desipramine, amitriptyline, and nortriptyline in biofluids was developed with a total run time of 8 min. The setup consists of two HPLC pumps, injection valve,... |
|
|
Ketobemidone is a substrate for cytochrome P4502C9 and 3A4, but not for P-glycoprotein.
Xenobiotica 35(8) , 785-96, (2005) The role of the major drug-metabolizing cytochrome P450 (CYP) enzymes as well as P-glycoprotein (PGP) was investigated in the disposition of ketobemidone in vitro. Formation of norketobemidone from ketobemidone was studied and compared with the activities of ... |