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3,4-二氢-5- [4-(1-哌啶基)丁氧基] -1(2H)-异喹啉酮

3,4-二氢-5- [4-(1-哌啶基)丁氧基] -1(2H)-异喹啉酮结构式
3,4-二氢-5- [4-(1-哌啶基)丁氧基] -1(2H)-异喹啉酮结构式
品牌特惠专场
常用名 3,4-二氢-5- [4-(1-哌啶基)丁氧基] -1(2H)-异喹啉酮 英文名 DPQ
CAS号 129075-73-6 分子量 302.41
密度 1.1±0.1 g/cm3 沸点 528.8±50.0 °C at 760 mmHg
分子式 C18H26N2O2 熔点 N/A
MSDS 美版 闪点 273.6±30.1 °C

DNA Double Strand Break Response and Limited Repair Capacity in Mouse Elongated Spermatids.

Int. J. Mol. Sci. 16 , 29923-35, (2015)

Spermatids are extremely sensitive to genotoxic exposures since during spermiogenesis only error-prone non homologous end joining (NHEJ) repair pathways are available. Hence, genomic damage may accumulate in sperm and be transmitted to the zygote. Indirect, d...

Parp1-XRCC1 and the repair of DNA double strand breaks in mouse round spermatids.

Mol. Cell. 683 , 84-90, (2010)

The repair of DNA double strand breaks (DSBs) in male germ cells is slower and differently regulated compared to that in somatic cells. Round spermatids show DSB repair and are radioresistant to apoptosis induction. Mutation induction studies using ionizing i...

Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia.

Nat. Med. 3 , 1089, (1997)

Nitric oxide (NO) and peroxynitrite, formed from NO and superoxide anion, have been implicated as mediators of neuronal damage following focal ischemia, but their molecular targets have not been defined. One candidate pathway is DNA damage leading to activati...

Dihydroisoquinolinones: the design and synthesis of a new series of potent inhibitors of poly(ADP-ribose) polymerase.

Anticancer Drug Des. 6 , 107, (1991)

A series of dihydroisoquinolinones, formally rigid analogs of 3-substituted benzamides, and a series of 2,3-disubstituted benzamides were synthesized and evaluated as inhibitors of poly(ADP-ribose) polymerase. The results indicated that the orientation of the...