1-(5-异喹啉磺酰基)-3-甲基哌嗪
1-(5-异喹啉磺酰基)-3-甲基哌嗪结构式
|
常用名 | 1-(5-异喹啉磺酰基)-3-甲基哌嗪 | 英文名 | 1-(5-ISOQUINOLINYLSULFONYL)-3-METHYL-PIPERAZINE |
|---|---|---|---|---|
| CAS号 | 84477-73-6 | 分子量 | 291.36900 | |
| 密度 | 1.277 g/cm3 | 沸点 | 495.3ºC at 760 mmHg | |
| 分子式 | C14H17N3O2S | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 253.3ºC |
|
Production of interleukin (IL)-6 and IL-8 by a choriocarcinoma cell line, BeWo.
Placenta 21(4) , 354-60, (2000) To clarify the biological and pathological features of choriocarcinoma, we evaluated the in vitro production of cytokines by a choriocarcinoma cell line, BeWo. We measured the concentration of interleukin (IL)-6 and IL-8 in the culture media of BeWo cells aft... |
|
|
Epidermal growth factor-induced heterologous desensitization of the luteinizing hormone/choriogonadotropin receptor in a cell-free membrane preparation is associated with the tyrosine phosphorylation of the epidermal growth factor receptor.
Endocrinology 140(1) , 29-36, (1999) Epidermal growth factor (EGF) attenuated hCG-stimulated adenylyl cyclase activity in rat luteal and follicular membranes. H7, an equipotent serine/threonine protein kinase inhibitor of cAMP-dependent protein kinases, cGMP-dependent protein kinases, and lipid-... |
|
|
Alpha1-adrenergic regulation of peptidylglycine alpha-amidating monooxygenase gene expression in cultured rat cardiac myocytes: transcriptional studies and messenger ribonucleic acid stability.
Mol. Cell. Endocrinol. 154(1-2) , 89-100, (1999) Peptidylglycine alpha-amidating monooxygenase (PAM; EC 1.14.17.3) is a bifunctional protein containing two enzymes that act sequentially to catalyse the alpha-amidation of neuroendocrine peptides. Previous studies have demonstrated that alpha-adrenergic stimu... |
|
|
Protein kinase C inhibition blocks the early appearance of vestibular compensation.
Brain Res. 845(1) , 97-101, (1999) This study tests the hypothesis that activation of protein kinase C (PKC) is a critical step for early recovery from spontaneous nystagmus after unilateral ablation of the vestibular periphery. Halothane-NO(2)-O(2)-anesthetized Long-Evans rats received a 5-mi... |
|
|
The enhancing mechanism of capric acid (C10) from a suppository on rectal drug absorption through a paracellular pathway.
Biol. Pharm. Bull. 20(4) , 446-8, (1997) Capric acid (C10) enhanced the absorption of cefoxitin sodium in a concentration-dependent manner following the rectal administration as a suppository in rats. The optimal concentration of C10 was 13%. C10 administered as a suppository also reduced rectal mem... |
|
|
The kinase inhibitor iso-H7 stimulates rat satellite cell differentiation through a non-protein kinase C pathway by increasing myogenin expression level.
Cell Biol. Toxicol. 12(3) , 177-85, (1996) We analysed the signaling pathways involved in myogenic differentiation of primary cultures of rat satellite cells using substances targeting the protein kinase C (PKC) and the cAMP protein kinase (PKA) pathways. We have previously shown that iso-H7, which pu... |
|
|
Three-dimensional collagen regulates collagen gene expression by a mechanism that requires serine/threonine kinases and is independent of mechanical contraction.
Biochem. Biophys. Res. Commun. 280(1) , 328-33, (2001) Integrin alpha1beta1, one of the cellular collagen receptors, can participate in the regulation of collagen accumulation by acting as a negative feedback regulator. The molecular mechanism behind this phenomenon has been unknown. We have plated cells inside t... |
|
|
Cyclosporine A-induced contractions and prostacyclin release are maintained by extracellular calcium in rat aortic rings: role of protein kinase C.
Prostaglandins Leukot. Essent. Fatty Acids 56(2) , 151-6, (1997) Chronic treatment with the immunosuppressive drug, Cyclosporine A (CsA), is associated with increased intracellular calcium in vascular smooth muscle cells, which may cause vasoconstriction and/or activate phospholipase A2. We used rat aortic rings to investi... |
|
|
Endothelin-induced prostacyclin production in rat aortic endothelial cells is mediated by protein kinase C.
Prostaglandins Leukot. Essent. Fatty Acids 60(4) , 263-8, (1999) Endothelin (ET) is a vasoconstrictor peptide released from endothelial cells that is known to cause prostaglandin (PG) release. The mechanism remains unclear. To determine whether the protein kinase C (PKC) signaling pathway is stimulated by endothelin, we pr... |
|
|
The leukocyte common antigen (CD45) on human pre-B leukemia cells: variant glycoprotein form expression during the cell exposure to phorbol ester is blocked by a nonselective protein kinase inhibitor H7.
Neoplasma 44(4) , 205-11, (1997) The human pre-B acute lymphoblastic leukemia cell line REH6 was utilized for characterization of CD45 glycoprotein by monoclonal antibodies (mAb) recognizing four distinct CD45 antigen specificities, i.e. nonrestricted CD45, restricted CD45RA, CD45RB and CD45... |