3-羟甲基-β-咔啉
3-羟甲基-β-咔啉结构式
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常用名 | 3-羟甲基-β-咔啉 | 英文名 | 3-HYDROXYMETHYL-BETA-CARBOLINE |
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| CAS号 | 65474-79-5 | 分子量 | 198.22100 | |
| 密度 | 1.385 g/cm3 | 沸点 | 466ºC at 760 mmHg | |
| 分子式 | C12H10N2O | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 235.6ºC |
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Do benzodiazepine receptors play a role in sleep regulation? Studies with the benzodiazepine antagonist, 3-hydroxymethyl-beta-carboline (3-HMC).
Prog. Clin. Biol. Res. 90 , 253-61, (1982)
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Electrophysiological studies on benzodiazepine antagonists.
Brain Res. 295(2) , 265-74, (1984) The actions of the benzodiazepine (BDZ) antagonists 3-hydroxymethyl-beta-carboline (3-HMC), Ro 14-7437 and Ro 15-1788 were tested on single cell activity of rat hypothalamic neurons in tissue cultures and on membrane properties of CA1 hippocampal pyramidal ne... |
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The interaction between benzodiazepine antagonists and barbiturate-induced cerebrovascular and cerebral metabolic depression.
Neuropharmacology 24(10) , 957-63, (1985) It has been reported that pentobarbital facilities binding to benzodiazepine receptors binding at anesthetic concentrations and that this action may play a role in the anesthetic potency of this barbiturate. The interaction between pentobarbital and benzodiaz... |
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3-hydroxymethyl-beta-carboline antagonizes some pharmacologic actions of diazepam.
Eur. J. Pharmacol. 69(4) , 525-7, (1981)
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A benzodiazepine receptor antagonist decreases sleep and reverses the hypnotic actions of flurazepam.
Science 219(4583) , 414-6, (1983) The benzodiazepine receptor antagonist 3-hydroxymethyl-beta-carboline, which blocks several of the pharmacological actions of benzodiazepines, induces a dose-dependent increase in sleep latency in the rat. Furthermore, at a low dose that by itself does not af... |
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Beta-carbolines as antagonists of the discriminative stimulus effects of diazepam in rats.
J. Pharmacol. Exp. Ther. 246(1) , 275-81, (1988) Rats were trained to discriminate between saline and 1.0 mg/kg of diazepam in a two-choice procedure where responding was maintained under a fixed-ratio, 5-response schedule of stimulus shock termination. beta-Carboline-3-carboxylate-methyl ester (beta CCM), ... |
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The benzodiazepine receptor and sleep.
Psychiatr. Dev. 2(3) , 161-77, (1984) The discovery of high affinity, stereoselective binding sites for benzodiazepines (BZ) was a major step in understanding the molecular mechanism by which these widely used sedative/hypnotics exert their various pharmacologic effects. It has become clear that ... |
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A benzodiazepine antagonist inhibits the cerebral metabolic and respiratory depressant effects of fentanyl.
Life Sci. 36(23) , 2239-45, (1985) It is reported that benzodiazepines such as diazepam will stimulate the opiate receptor system and that B-carboline drugs, which are benzodiazepine antagonists, may interact with opiate receptors directly. The ability of 3-hydroxymethyl-B-carboline (3-HMC) to... |
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Cerebrovascular and cerebral metabolic effects of flurazepam and a benzodiazepine antagonist, 3-hydroxymethyl-beta-carboline.
Eur. J. Pharmacol. 106(3) , 585-91, (1984) There is a need in clinical practice for an antagonist which can reverse the sedative action of benzodiazepines. Recently, 3-hydroxymethyl-beta-carboline (3-HMC) has been reported to inhibit the sleep inducing effects of flurazepam. The effects of flurazepam ... |