L-天冬氨酰-β-异羟肟酸
L-天冬氨酰-β-异羟肟酸结构式
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常用名 | L-天冬氨酰-β-异羟肟酸 | 英文名 | L-Asparagine,N-hydroxy- |
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| CAS号 | 1955-68-6 | 分子量 | 148.11700 | |
| 密度 | 1.532g/cm3 | 沸点 | N/A | |
| 分子式 | C4H8N2O4 | 熔点 | 171-172 °C | |
| MSDS | 中文版 美版 | 闪点 | N/A |
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Blockade of PD1 and TIM3 restores innate and adaptive immunity in patients with acute alcoholic hepatitis.
Gastroenterology 148(3) , 590-602.e10, (2015) Susceptibility to bacterial infection is a feature of alcohol-related liver disease. Programmed cell death 1 (PD1), the T-cell immunoglobulin and mucin domain-containing protein 3 (TIM3, also known as hepatitis A virus cellular receptor 2), and their respecti... |
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Continuous and pulsed hydrogen-deuterium exchange and mass spectrometry characterize CsgE oligomerization.
Biochemistry 54 , 6475-81, (2015) We report the use of hydrogen-deuterium amide exchange coupled to mass spectrometry (HDX-MS) to study the interfaces of and conformational changes accompanying CsgE oligomerization. This protein plays an important role in enteric bacteria biofilm formation. B... |
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A Novel Role of E-Cadherin-Based Adherens Junctions in Neoplastic Cell Dissemination.
PLoS ONE 10 , e0133578, (2015) Using confocal microscopy, we analyzed the behavior of IAR-6-1, IAR1170, and IAR1162 transformed epithelial cells seeded onto the confluent monolayer of normal IAR-2 epithelial cells. Live-cell imaging of neoplastic cells stably expressing EGFP and of normal ... |
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Hydroxamic acids as a novel family of serine racemase inhibitors: mechanistic analysis reveals different modes of interaction with the pyridoxal-5'-phosphate cofactor.
J. Med. Chem. 52 , 6032-41, (2009) Mammalian serine racemase (SR) is a pyridoxal-5'-phosphate (PLP) dependent enzyme responsible for the biosynthesis of the neurotransmitter D-serine, which activates N-methyl-D-aspartate (NMDA) receptors in the CNS. Aberrant regulation of NMDA receptor signali... |
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Estrogen-dependent regulation of human uterine natural killer cells promotes vascular remodelling via secretion of CCL2.
Hum. Reprod. 30 , 1290-301, (2015) Does intrauterine biosynthesis of estrogen play an important role in early pregnancy by altering the function of uterine natural killer (uNK) cells?Estrogens directly regulate the function of human uNK cells by increasing uNK cell migration and secretion of u... |
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CTNNBL1 facilitates the association of CWC15 with CDC5L and is required to maintain the abundance of the Prp19 spliceosomal complex.
Nucleic Acids Res. 43 , 7058-69, (2015) In order to catalyse the splicing of messenger RNA, multiple proteins and RNA components associate and dissociate in a dynamic highly choreographed process. The Prp19 complex is a conserved essential part of the splicing machinery thought to facilitate the co... |
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4-methylthio 2-oxobutanoate transaminase: a specific target for antiproliferative agents.
Bull. Cancer 91(4) , E61-79, (2004) We have previously shown that the addition of 4-methylthio-2-oxobutanoate (MTOB) to cultures of methionine dependent neoplastic cells which lack endogenous MTOB restores their capacity to grow in the absence of exogenous methionine. Transition state inhibitor... |
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Monohydroxamates of aspartic acid and glutamic acid exhibit antioxidant and angiotensin converting enzyme inhibitory activities.
J. Agric. Food Chem. 52 , 2386-90, (2004) Two monohydroxamates of l-aspartic acid beta-hydroxamate (AAH) and l-glutamic acid gamma-hydroxamate (GAH) were used for testing antioxidant and angiotensin converting enzyme (ACE) inhibitory activities in comparison with those of asparagine and glutamine, re... |
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Genome-scale analysis of anti-metabolite directed strain engineering.
Metab. Eng. 10(2) , 109-20, (2008) Classic strain engineering methods have previously been limited by the low-throughput of conventional sequencing technology. Here, we applied a new genomics technology, scalar analysis of library enrichments (SCALEs), to measure >3 million Escherichia coli ge... |
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Inhibition of excitatory amino acid-stimulated phosphoinositide hydrolysis in rat hippocampus by L-aspartate-beta-hydroxamate.
Brain Res. 572(1-2) , 103-7, (1992) The effect of a series of glutamate uptake inhibitors was tested on ibotenate-stimulated phosphoinositide hydrolysis. The pharmacological profile of the inhibitory effect of these compounds on the ibotenate response was quite different from that on glutamate ... |