己酰神经鞘氨醇
己酰神经鞘氨醇结构式
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常用名 | 己酰神经鞘氨醇 | 英文名 | N-(hexanoyl)sphing-4-enine |
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| CAS号 | 124753-97-5 | 分子量 | 397.63 | |
| 密度 | 0.9±0.1 g/cm3 | 沸点 | 574.7±50.0 °C at 760 mmHg | |
| 分子式 | C24H47NO3 | 熔点 | 76-77ºC | |
| MSDS | 中文版 美版 | 闪点 | 301.4±30.1 °C |
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Stimulation of the cardiac myocyte Na+-K+ pump due to reversal of its constitutive oxidative inhibition.
Am. J. Physiol. Cell Physiol. 309 , C239-50, (2015) Protein kinase C can activate NADPH oxidase and induce glutathionylation of the β1-Na(+)-K(+) pump subunit, inhibiting activity of the catalytic α-subunit. To examine if signaling of nitric oxide-induced soluble guanylyl cyclase (sGC)/cGMP/protein kinase G ca... |
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Carbon nanoparticles induce ceramide- and lipid raft-dependent signalling in lung epithelial cells: a target for a preventive strategy against environmentally-induced lung inflammation.
Part. Fibre Toxicol. 9 , 48, (2012) Particulate air pollution in lung epithelial cells induces pathogenic endpoints like proliferation, apoptosis, and pro-inflammatory reactions. The activation of the epidermal growth factor receptor (EGFR) is a key event responsible for signalling events invol... |
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Targeting sphingosine kinase 2 (SphK2) by ABC294640 inhibits colorectal cancer cell growth in vitro and in vivo.
J. Exp. Clin. Cancer Res 34 , 94, (2015) Colorectal cancer (CRC) is a major health problem in China and around the world. It is one of the leading causes of cancer-related deaths. Research groups are thus searching for novel and more efficient anti-CRC agents.Here we demonstrated that ABC294640, a n... |
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Mix and measure fluorescence screening for selective quadruplex binders.
Nucleic Acids Res. 36 , e106, (2008) The human genome contains thousands of regions, including that of the telomere, that have the potential to form quadruplex structures. Many of these regions are potential targets for therapeutic intervention. There are many different folding patterns for quad... |
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Glioma cell death induced by irradiation or alkylating agent chemotherapy is independent of the intrinsic ceramide pathway.
PLoS ONE 8(5) , e63527, (2013) Resistance to genotoxic therapy is a characteristic feature of glioma cells. Acid sphingomyelinase (ASM) hydrolyzes sphingomyelin to ceramide and glucosylceramide synthase (GCS) catalyzes ceramide metabolism. Increased ceramide levels have been suggested to e... |
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Synthesis, NMR characterization and divergent biological actions of 2′-hydroxy-ceramide/dihydroceramide stereoisomers in MCF7 cells
Bioorg. Med. Chem. 18 , 7565-79, (2010) A straightforward method for the simultaneous preparation of (2S,3R,2'R)- and (2S,3R,2'S)-2'-hydroxy-ceramides (2'-OHCer) from (2S,3R)-sphingosine acetonide precursors and racemic mixtures of 2-hydroxy fatty acids (2-OHFAs) is described. The obtained 2'-OH-C4... |
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Ceramides: branched alkyl chains in the sphingolipid siblings of diacylglycerol improve biological potency.
Bioorg. Med. Chem. 17 , 1498-505, (2009) The synthesis of a small number of ceramide analogues containing a combination of linear and highly branched alkyl chains on either the d-sphingosine or the N-acyl core of the molecule is reported. Regardless of location, the presence of the branched chain im... |
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Macrophage TNF mRNA expression induced by LPS is regulated by sphingomyelin metabolites.
Shock 11 , 411-415, (1999) Metabolism of macrophage (MO) membrane phospholipids produces key mediators of inflammation and major second messengers that modulate inflammatory responses during sepsis. Sphingomyelin is a major class of phospholipid that releases ceramide and sphingosine. ... |
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Induction of the manganese superoxide dismutase gene by sphingomyelinase and ceramide.
J. Neurochem. 73 , 513-520, (1999) The present study reports the effect of ceramide generated by hydrolysis of membrane sphingomyelin with bacterial sphingomyelinase (SMase) and of cell-permeable ceramide analogues on the expression of manganese superoxide dismutase (MnSOD). Incubation of the ... |
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Microbial sphingomyelinase induces RhoA-mediated reorganization of the apical brush border membrane and is protective against invasion.
Mol. Biol. Cell 27 , 1120-30, (2016) The apical brush border membrane (BBM) of intestinal epithelial cells forms a highly structured and dynamic environmental interface that serves to regulate cellular physiology and block invasion by intestinal microbes and their products. How the BBM dynamical... |