3,3,5,5-四甲基-1-吡咯啉-N-氧化物 [自旋捕集试剂]
![3,3,5,5-四甲基-1-吡咯啉-N-氧化物 [自旋捕集试剂]结构式](https://image.chemsrc.com/caspic/360/10135-38-3.png)
3,3,5,5-四甲基-1-吡咯啉-N-氧化物 [自旋捕集试剂]结构式
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常用名 | 3,3,5,5-四甲基-1-吡咯啉-N-氧化物 [自旋捕集试剂] | 英文名 | 3,3,5,5-tetramethyl-1-pyrroline n-oxide |
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| CAS号 | 10135-38-3 | 分子量 | 141.211 | |
| 密度 | 0.9±0.1 g/cm3 | 沸点 | 251.0±0.0 °C at 760 mmHg | |
| 分子式 | C8H15NO | 熔点 | 58-61 ℃(lit.) | |
| MSDS | 美版 | 闪点 | 113.3±11.5 °C |
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Use of 3,3,5,5-tetramethyl-1-pyrroline-1-oxide spin trap for the continuous flow ESR monitoring of hydroxyl radical generation in the ischemic and reperfused myocardium.
Biochem. Biophys. Res. Commun. 164(3) , 1274-80, (1989) A new approach for in vivo spin trapping and quantitation of oxygen-derived free radicals has been developed using a continuous flow high speed ESR detection system. Spin adducts of OH. were detected as 1:1:1:1:1:1 sextets (aN=15.2 G, aH=16.8 G, g=2.0055) in ... |
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The effect of myoglobin on the stability of the hydroxyl-radical adducts of 5,5 dimethyl-1-pyrolline-N-oxide (DMPO), 3,3,5,5 tetramethyl-1-pyrolline-N-oxide (TMPO) and 1-alpha-phenyl-tert-butyl nitrone (PBN) in the presence of hydrogen peroxide.
Free Radic. Res. 20(5) , 327-32, (1994) The hydroxyl radical adducts of 5,5 dimethyl-1-pyrolline-N-oxide (DMPO) and 3,3,5,5 tetramethyl-1-pyrolline-N-oxide (TMPO) formed in the presence of hydrogen peroxide and FeII are normally quite stable, but in the presence of 5-20 micromolar myoglobin their E... |
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Oxidation of spin-traps by chlorine dioxide (ClO2) radical in aqueous solutions: first ESR evidence of formation of new nitroxide radicals.
Free Radic. Biol. Med. 20(6) , 837-41, (1996) The reactivities of the chlorine dioxide (ClO2), which is a stable free radical towards some water-soluble spin-traps were investigated in aqueous solutions by an electron spin resonance (ESR) spectroscopy. The ClO2 radical was generated from the redox reacti... |
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Spectral editing based on selective excitation and Lee-Goldburg cross-polarization under magic angle spinning.
Solid State Nucl. Magn. Reson. 29(4) , 272-7, (2006) We show that a Gaussian-shaped pulse can be used to excite selected 1H signals in hydroxyapatite, monetite and H-Y zeolite loaded with trimethylphosphine oxide (TMPO). This selective excitation method can be incorporated into Lee-Goldburg (LG) cross-polarizat... |
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Use of M4PO and oxygen-17 in the study on hydroxyl radical generation in the hypoxanthine-xanthine oxidase reaction.
Biochem. Mol. Biol. Int. 32(3) , 523-9, (1994) To determine whether hydroxyl radicals (.OH) are generated in the hypoxanthine (HPX)-xanthine oxidase (XOD) reaction, we examined the electron paramagnetic resonance (EPR) spectra of the spin adducts formed. In the EPR study, we used 3,3,5,5-tetramethyl-1-pyr... |
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Biological spin trapping. II. Toxicity of nitrone spin traps: dose-ranging in the rat.
J. Biochem. Biophys. Methods 30 , 239-247, (1995) To obtain the strongest possible free radical spin adduct signal using the electron paramagnetic resonance spectroscopy-spin trapping technique, it is desirable to load an animal with the highest dose of spin trap possible. One hundred and twenty six male Spr... |
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Synthesis of spin traps specific for hydroxyl radical.
J. Med. Chem. 31(2) , 428-32, (1988) Two nitrones, 3,3-diethyl-5,5-dimethylpyrroline 1-oxide (DEDMPO) and 3,3,5,5-tetramethylpyrroline 1-oxide (M4PO), were synthesized by the zinc/ammonium chloride reduction of appropiately substituted gamma-nitrocarbonyl compounds, followed by addition of methy... |
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Real-time continuous-flow spin trapping of hydroxyl free radical in the ischemic and post-ischemic myocardium.
Eur. J. Biochem. 186(1-2) , 163-73, (1989) Real-time monitoring of spin-trapped oxygen-derived free radicals released by the isolated ischemic and reperfused rat heart has been achieved by ESR analysis of the coronary effluents using continuous flow detection and high-speed acquisition techniques. Two... |
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Endothelial cells as a source of oxygen-free radicals. An ESR study.
Free Radic. Res. Commun. 9(3-6) , 287-96, (1990) Endothelial cells were subjected to anoxia/reoxygenation in order to simulate some of the free radical mechanisms occurring in ischaemia/reperfusion. With ESR and spin trapping using the spin traps 5,5-dimethyl-1-pyrroline-1-oxide (DMPO) and 3,3,5,5-dimethyl-... |
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Death of cerebellar granule neurons induced by piperine is distinct from that induced by low potassium medium.
Neurochem. Res. 23(1) , 97-102, (1998) We compared neurotoxicity of piperine and low K+ on cultured cerebellar granule neurons. As considered from lactate dehydrogenase release and 3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyl tetrazolium bromide reduction, both piperine and shifting from high K+ (25 ... |