Lorglumide钠盐
Lorglumide钠盐结构式
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常用名 | Lorglumide钠盐 | 英文名 | Lorglumide sodium salt |
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| CAS号 | 1021868-76-7 | 分子量 | 481.388 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C22H31Cl2N2NaO4 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | N/A |
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Different downstream signalling of CCK1 receptors regulates distinct functions of CCK in pancreatic beta cells.
Br. J. Pharmacol. 172 , 5050-67, (2015) Cholecystokinin (CCK) is secreted by intestinal I cells and regulates important metabolic functions. In pancreatic islets, CCK controls beta cell functions primarily through CCK1 receptors, but the signalling pathways downstream of these receptors in pancreat... |
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Involvement of different subtypes of cholecystokinin receptors in opioid antinociception in the mouse.
Peptides 16(7) , 1229-34, (1995) Various doses of sulfated cholecystokinin octapeptide (CCK-8s) injected intracerebroventricularly (ICV) alone did not show any antinociceptive effect. CCK-8s (0.01-1 ng) pretreated ICV for 10 min dose-dependently attenuated the inhibition of the tail flick re... |
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Expression of the transcription factor Egr-1 in pancreatic acinar cells following stimulation of cholecystokinin or Gαq-coupled designer receptors.
Cell Physiol. Biochem. 33(5) , 1411-25, (2014) BACKGOUND/AIMS: The injection of cerulein, an analogue of the pancreatic secretagogue cholecystokinin (CCK), induces acute pancreatitis in mice that is accompanied by the synthesis of the transcription factor Egr-1. The signaling cascade that connects cerulei... |
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Identification of N-arachidonylglycine, U18666A, and 4-androstene-3,17-dione as novel insulin Secretagogues.
Biochem. Biophys. Res. Commun. 333(3) , 778-86, (2005) The glucose-induced insulin secretion is fine-tuned by numerous factors. To systematically identify insulinotropic factors, we optimized a primary beta-cell-based functional assay to monitor intracellular Ca2+ flux ([Ca2+]i). By this assay system, we successf... |
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Pharmacological properties of lorglumide as a member of a new class of cholecystokinin antagonists.
Arzneimittelforschung 37 , 1265-1268, (1987) Derivatives of 5-(dipentylamino)-5-oxo-pentanoic acid are a new class of non-peptide cholecystokinin (CCK) antagonists. The most potent compound, D,L-4-(3,4-dichlorobenzoylamino)-5-(dipentylamino)-5-oxo-pen tanoic acid (lorglumide, CR 1409), has a great affin... |
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Studies of three non-peptide cholecystokinin antagonists (devazepide, lorglumide and loxiglumide) in human isolated alimentary muscle and guinea-pig ileum.
Br. J. Pharmacol. 102 , 391-395, (1991) 1. Three recently described non-peptide cholecystokinin (CCK) antagonists (devazepide, lorglumide, loxiglumide) have been studied for their antagonism of the contraction to cholecystokinin-octapeptide (CCK-OP) in human alimentary muscle and guinea-pig intesti... |
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The role of brain-gut peptides in the control of sodium appetite.
Ann. N. Y. Acad. Sci. 897 , 192-197, (1999) Ingestion of food and fluid stimulates release of a number of peptides from the gastrointestinal system. These peptides are recognized to act as neurotransmitters/neuromodulators and act at both peripheral and central receptors. Many studies indicate that the... |