8-hydroxy-2'-deoxyguanosine

Names

[ Name ]:
8-hydroxy-2'-deoxyguanosine

[Synonym ]:
2'-deoxy-7,8-dihydro-8-oxo-guanosine
MFCD00210311
2'-Deoxy-8-oxo-7,8-dihydroguanosine
7,8-Dihydro-8-oxo-2'-deoxyguanosine
2'-Deoxy-8-oxoguanosine
8-Oxo-7,8-dihydrodeoxyguanosine
2'-Deoxy-8-oxo-D-guanosine
8-Oxodeoxyguanosine
guanosine, 2'-deoxy-8-oxo-
2'-Deoxy-8-hydroxyguanosine
8-oxo-7,8-dihydro-2'-deoxiguanosine
Guanosine, 2'-deoxy-8-hydroxy-
8-oxo-7-hydrodeoxyguanosine
8-hydroxydeoxyguanosine
8-HYDROXY-2'-DEOXYGUANOSINE
8-Hydroxy-2’-deoxyguanosine
8-oxo-7,8-dihydro-2'-deoxyguanosine
2'-Deoxy-7,8-dihydro-8-oxoguanosine

Biological Activity

[Description]:

8-Hydroxy-2'-deoxyguanosine is a critical biomarker of oxidative stress and carcinogenesis.

[Related Catalog]:

Research Areas >> Cancer

Natural Products >> Others

[Target]

Human Endogenous Metabolite

[In Vitro]

8-Hydroxy-2'-deoxyguanosine (8-OHdG) is a good biomarker for risk assessment of various cancers and degenerative diseases. The biomarker 8-Hydroxy-2'-deoxyguanosine (8-OHdG) or 8-oxodG has been a pivotal marker for measuring the effect of endogenous oxidative damage to DNA and as a factor of initiation and promotion of carcinogenesis. The biomarker has been used to estimate the DNA damage in humans after exposure to cancer-causing agents, such as tobacco smoke, asbestos fibers, heavy metals, and polycyclic aromatic hydrocarbons[1].

[References]

[1]. Valavanidis A, et al. 8-hydroxy-2' -deoxyguanosine (8-OHdG): A critical biomarker of oxidative stress and carcinogenesis. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2009 Apr;27(2):120-39.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
2.3±0.1 g/cm3

[ Melting Point ]:
217-220ºC

[ Molecular Formula ]:
C₁₀H₁₃N₅O₅

[ Molecular Weight ]:
283.241

[ Exact Mass ]:
283.091675

[ PSA ]:
159.51000

[ LogP ]:
-1.32

[ Index of Refraction ]:
1.955

[ Storage condition ]:
2-8°C

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
MF8782675

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

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NADPH oxidase plays a central role in mediating oxidative stress during heart, liver, and lung ischemia/reperfusion injury, but limited information is available about NADPH oxidase in renal ischemia/r...

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The present study was designed to evaluate the influence of long-term environmental human exposure to three heavy metals, lead (Pb), cadmium (Cd), and mercury (Hg), on the expression of detoxifying, x...