YM-244769

Modify Date: 2024-01-14 10:17:07

YM-244769 structure	Common Name	YM-244769
	CAS Number	838819-70-8	Molecular Weight	443.47
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₆H₂₂FN₃O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of YM-244769

YM-244769 is a potent NCX (Na+/Ca2+ exchange) inhibitor that preferentially inhibits NCX3, with an IC50 of 18 nM. YM-244769 efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage[1].

Name	YM-244769

Description	YM-244769 is a potent NCX (Na+/Ca2+ exchange) inhibitor that preferentially inhibits NCX3, with an IC50 of 18 nM. YM-244769 efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage[1].
Related Catalog	Research Areas >> Neurological Disease
Target	IC50: 18 nM (NCX3)[1]
In Vitro	YM-244769 preferentially inhibits intracellular Na+-dependent 45Ca2+ uptake via NCX3; the inhibition is 3.8- to 5.3-fold greater than for the uptake via NCX1 or NCX2[1].
References	[1]. Iwamoto T, Kita S. YM-244769, a novel Na+/Ca2+ exchange inhibitor that preferentially inhibits NCX3, efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage. Mol Pharmacol. 2006 Dec;70(6):2075-83.

Molecular Formula	C₂₆H₂₂FN₃O₃
Molecular Weight	443.47