YM 750

Modify Date: 2024-01-08 08:27:19

YM 750 structure	Common Name	YM 750
	CAS Number	138046-43-2	Molecular Weight	452.63000
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₁H₃₆N₂O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of YM 750

YM-750 is a potent acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor (IC50=0.18 μM). ACAT catalyzes the formation of cholesteryl esters from cholesterol and long-chain fatty-acyl-coenzyme A[1][2].

Name	1-cycloheptyl-1-(9H-fluoren-2-ylmethyl)-3-(2,4,6-trimethylphenyl)urea
Synonym	More Synonyms

Description	YM-750 is a potent acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor (IC50=0.18 μM). ACAT catalyzes the formation of cholesteryl esters from cholesterol and long-chain fatty-acyl-coenzyme A[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease
In Vitro	Foam cells accumulated esterified cholesterol (EC) for 24 h in the presence of acLDL without Cu2+, which is suppressed by KY-455 and YM-750[3].
References	[1]. Nagata Y, et al. N-[2-[N'-pentyl-(6,6-dimethyl-2,4-heptadiynyl)amino]ethyl]- (2-methyl-1-naphthylthio)acetamide (FY-087). A new acyl coenzyme a:cholesterol acyltransferase (ACAT) inhibitor of diet-induced atherosclerosis formation in mice. Biochem Pharmacol. 1995;49(5):643-651. [2]. Chang C, et al. Human acyl-CoA:cholesterol acyltransferase (ACAT) and its potential as a target for pharmaceutical intervention against atherosclerosis. Acta Biochim Biophys Sin (Shanghai). 2006;38(3):151-156. [3]. Miike T, et al. Effects of an anti-oxidative ACAT inhibitor on apoptosis/necrosis and cholesterol accumulation under oxidative stress in THP-1 cell-derived foam cells. Life Sci. 2008;82(1-2):79-84.

Molecular Formula	C₃₁H₃₆N₂O
Molecular Weight	452.63000
Exact Mass	452.28300
PSA	35.83000
LogP	7.95350

ym 750

DC Chemicals Limited
China
Product Name: YM-750
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: N-Cycloheptyl-N-(9H-fluoren-2-ylmethyl)-N'-(2,4,6-trimethylphenyl)urea
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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YM 750

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