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YM 750

Names

[ CAS No. ]:
138046-43-2

[ Name ]:
YM 750

[Synonym ]:
ym 750

Biological Activity

[Description]:

YM-750 is a potent acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor (IC50=0.18 μM). ACAT catalyzes the formation of cholesteryl esters from cholesterol and long-chain fatty-acyl-coenzyme A[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

[In Vitro]

Foam cells accumulated esterified cholesterol (EC) for 24 h in the presence of acLDL without Cu2+, which is suppressed by KY-455 and YM-750[3].

[References]

[1]. Nagata Y, et al. N-[2-[N'-pentyl-(6,6-dimethyl-2,4-heptadiynyl)amino]ethyl]- (2-methyl-1-naphthylthio)acetamide (FY-087). A new acyl coenzyme a:cholesterol acyltransferase (ACAT) inhibitor of diet-induced atherosclerosis formation in mice. Biochem Pharmacol. 1995;49(5):643-651.

[2]. Chang C, et al. Human acyl-CoA:cholesterol acyltransferase (ACAT) and its potential as a target for pharmaceutical intervention against atherosclerosis. Acta Biochim Biophys Sin (Shanghai). 2006;38(3):151-156.

[3]. Miike T, et al. Effects of an anti-oxidative ACAT inhibitor on apoptosis/necrosis and cholesterol accumulation under oxidative stress in THP-1 cell-derived foam cells. Life Sci. 2008;82(1-2):79-84.

Chemical & Physical Properties

[ Molecular Formula ]:
C31H36N2O

[ Molecular Weight ]:
452.63000

[ Exact Mass ]:
452.28300

[ PSA ]:
35.83000

[ LogP ]:
7.95350

Related Compounds