1780390-65-9
1780390-65-9 structure
- Name: YM-244769 dihydrochloride
- Chemical Name: YM-244769 dihydrochloride
- CAS Number: 1780390-65-9
- Molecular Formula: C26H24Cl2FN3O3
- Molecular Weight: 516.39
- Catalog: Research Areas Neurological Disease
- Create Date: 2020-08-11 16:55:13
- Modify Date: 2024-01-14 19:36:47
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YM-244769 dihydrochloride is a potent Na+/Ca2+ exchange (NCX) inhibitor that preferentially inhibits NCX3 (IC50=18 nM). Neuronal and renal protection[1].
| Name | YM-244769 dihydrochloride |
|---|
| Description | YM-244769 dihydrochloride is a potent Na+/Ca2+ exchange (NCX) inhibitor that preferentially inhibits NCX3 (IC50=18 nM). Neuronal and renal protection[1]. |
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| Related Catalog | |
| In Vitro | YM-244769 preferentially inhibits intracellular Na+-dependent 45Ca2+ uptake via NCX3 (IC50=18 nM); the inhibition is 3.8- to 5.3-fold greater than for the uptake via NCX1 or NCX2, but it does not significantly affect extracellular Na+-dependent 45Ca2+ efflux via NCX isoforms[1]. YM-244769 (0.003-1 μM) inhibits dose dependently the initial rates of 45Ca2+ uptake into NCX1, NCX2, and NCX3 transfectants with IC50 values of 68±2.9, 96±3.5, and 18±1.0 nM, respectively, indicating that YM-244769 is approximately four to five times more selective to NCX3 than other isoforms[1]. YM-244769 (0.3 or 1 μM) efficiently suppresses the hypoxia/reoxygenation-induced cell damage in SH-SY5Y cells treated with NCX1 antisense (i.e., SH-SY5Y cells primarily expressing NCX3) more than in those treated with NCX3 antisense (i.e., SH-SY5Y cells primarily expressing NCX1)[1]. Cell Viability Assay[1] Cell Line: SH-SY5Y cells treated with NCX1 or NCX3 antisense Concentration: 0.3 and 1 μM Incubation Time: Result: Hypoxia/reoxygenation-induced LDH release was significantly attenuated: reduction in cell damage was greater in cells treated with NCX3 antisense (by 61%) than in cells treated with NCX1 antisense (by 35%). 0.3 or 1 μM efficiently suppressed the hypoxia/reoxygenation-induced cell damage in SH-SY5Y cells treated with NCX1 antisense more than in those treated with NCX3 antisense. |
| References |
| Molecular Formula | C26H24Cl2FN3O3 |
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| Molecular Weight | 516.39 |
| Hazard Codes | Xi |
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