1020067-28-0
1020067-28-0 structure
- Name: YM-359445
- Chemical Name: YM-359445
- CAS Number: 1020067-28-0
- Molecular Formula: C32H34N6O8S
- Molecular Weight: 662.718
- Create Date: 2020-01-19 22:42:57
- Modify Date: 2023-01-15 13:30:31
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A highly potent, orally active VEGFR-2 inhibitor with IC50 of 8.5 nM, without activity against PKA, PKCα, PDK-1 and JNK3 (IC50>1 uM); inhibits VEGFR2 tyrosine kinase activity completely at 0.03 uM, inhibits HUVEC proliferation induced by VEGF with IC50 of 1.5 nM; inhibits VEGF-stimulated autophosphorylation of VEGFR2 at 0.1 nM, also inhibits sprout formation of endothelial cells at 3 nM; not only inhibits tumor growth but also reduces its vasculature in mice bearing various tumors, including paclitaxel-resistant tumors.
| Name | YM-359445 |
|---|
| Description | A highly potent, orally active VEGFR-2 inhibitor with IC50 of 8.5 nM, without activity against PKA, PKCα, PDK-1 and JNK3 (IC50>1 uM); inhibits VEGFR2 tyrosine kinase activity completely at 0.03 uM, inhibits HUVEC proliferation induced by VEGF with IC50 of 1.5 nM; inhibits VEGF-stimulated autophosphorylation of VEGFR2 at 0.1 nM, also inhibits sprout formation of endothelial cells at 3 nM; not only inhibits tumor growth but also reduces its vasculature in mice bearing various tumors, including paclitaxel-resistant tumors. |
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| References | References 1. Amino N, et al. Clin Cancer Res. 2006 Mar 1;12(5):1630-8. View Related Products by Target VEGFR |
| Molecular Formula | C32H34N6O8S |
|---|---|
| Molecular Weight | 662.718 |