GNTI dihydrochloride structure
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Common Name | GNTI dihydrochloride | ||
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CAS Number | 351183-88-5 | Molecular Weight | 529.458 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C27H30Cl2N4O3 | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of GNTI dihydrochloride5'-Guanidinonaltrindole (5'-GNTI) hydrochloride is a highly selective and potent κ-opioid receptor antagonist with a Ki of 0.18 nM for human κ-opioid receptor[1]. |
Name | N-[(1S,2S,13R)-22-(Cyclopropylmethyl)-2,16-dihydroxy-14-oxa-11,22-diazaheptacyclo[13.9.1.01,13.02,21.04,12.05,10.019,25]pentacosa-4(12),5,7,9,15(25),16,18-heptaen-7-yl]imidoformamide dihydrochloride |
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Synonym | More Synonyms |
Description | 5'-Guanidinonaltrindole (5'-GNTI) hydrochloride is a highly selective and potent κ-opioid receptor antagonist with a Ki of 0.18 nM for human κ-opioid receptor[1]. |
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Related Catalog | |
Target |
human κ-opioid receptor:0.18 nM (Ki) human κ-opioid receptor:10.4 (pA2) human μ-opioid receptor:36.9 nM (Ki) human μ-opioid receptor:8.49 (pA2) human δ-opioid receptor:70.0 nM (Ki) human δ-opioid receptor:7.81 (pA2) |
In Vitro | 5'-Guanidinonaltrindole (5'-GNTI) also binds to human μ- and δ-opioid receptors with Kis of 36.9±2.3 nM and 70.0±0.3 nM, respectively[1]. 5'-Guanidinonaltrindole is most effective at κ-opioid receptors (pA2=10.4±0.10), with substantially lower antagonist potency at μ-opioid (pA2=8.49±0.09) and δ-opioid receptors (pA2=7.81±0.06)[1]. |
In Vivo | 5'-Guanidinonaltrindole (5'-GNTI) (0.03-3 mg/kg; s.c.; once) induces scratching in mice[2]. Animal Model: Male Swiss-Webster mice[2] Dosage: 0.03, 0.1, 0.3, 1 and 3 mg/kg Administration: Subcutaneous injection, once Result: Induced scratching, the scratch A50 value was calculated to be 0.17 mg/kg. |
References |
Molecular Formula | C27H30Cl2N4O3 |
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Molecular Weight | 529.458 |
Exact Mass | 528.169495 |
Methanimidamide, N-[(4bS,8aS,14bR)-7-(cyclopropylmethyl)-5,6,7,8,8a,9,14,14b-octahydro-1,8a-dihydroxy-4,8-methanobenzofuro[2,3-a]pyrido[4,3-b]carbazol-11-yl]-, hydrochloride (1:2) |
N-[(1S,2S,13R)-22-(Cyclopropylmethyl)-2,16-dihydroxy-14-oxa-11,22-diazaheptacyclo[13.9.1.01,13.02,21.04,12.05,10.019,25]pentacosa-4(12),5,7,9,15(25),16,18-heptaen-7-yl]imidoformamide dihydro chloride |